Durolane Dosing Schedule and Prescribing Information

Last Updated On: September 19, 2024

Viscosupplements, such as hyaluronic acid injections, are commonly used to manage osteoarthritis pain, with treatment regimens ranging from single-dose injections to multiple doses administered weekly. These injections help lubricate and cushion the joint, providing relief from pain and improving mobility.

Durolane, a leading hyaluronic acid injection, stands out for its single-dose administration. It offers pain relief that can last up to six months. Unlike other treatments requiring multiple sessions over several weeks, Durolane’s convenience and extended effects make it a favored choice for many patients. 

This article will delve into the standard Durolane dosing schedule, its prescribing information, and how it compares to other treatments, helping you make an informed choice in managing knee osteoarthritis.

Key Takeaways

• Durolane is a single-injection treatment containing a high concentration of hyaluronic acid (HA) that mimics the natural synovial fluid found in healthy joints. It provides pain relief and improves joint function in patients with osteoarthritis.
• It is commonly used to treat osteoarthritis in various joints, including knees, hips, and shoulders, offering up to six months of pain relief.
• The standard dosage for Durolane is 3 mL per joint, and it is typically administered as a single injection, with effects lasting up to six months.
• Durolane is suitable for patients with mild to moderate osteoarthritis who have not responded adequately to conservative treatments and are seeking a non-surgical option to manage joint pain and improve mobility.

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What is Durolane?

Durolane is a single-injection treatment that contains a high concentration of hyaluronic acid (HA), a naturally occurring substance in the body that helps lubricate and cushion joints. It is primarily used to provide pain relief and improve joint function in patients with osteoarthritis.

It mimics the natural synovial fluid found in healthy joints. The hyaluronic acid in Durolane acts as a lubricant and shock absorber, reducing friction and pain in the affected joint. This helps to restore mobility and improve the overall quality of life for patients.

Conditions Treated with Durolane

Durolane is commonly used to treat osteoarthritis in various joints, including:

• Knees: The most frequent application, providing up to six months of pain relief.
• Hips: Durolane for hips helps alleviate pain and improve joint function.
• Shoulders: Durolane injection for shoulder pain is another effective use, offering relief from osteoarthritis symptoms.

Durolane Dosing Schedule

Durolane is typically administered as a single injection. The effects of this treatment can last up to six months, providing long-term relief from osteoarthritis symptoms.

The standard dosage for Durolane is 3 mL per joint. This dosage is consistent whether the injection is for the knee, hip, or shoulder. It is important to use separate syringes for each joint to ensure proper dosing and avoid contamination.

Administration Instructions

Before administering Durolane, ensure that the injection area is sterile to prevent infection. The procedure involves inserting a fine needle into the joint space under sterile conditions. Patients are typically positioned comfortably, and local anesthetic may be used to minimize discomfort during the injection. It is essential to follow proper aseptic techniques and avoid injecting into areas of infection or severely inflamed joints.

Adhering to the recommended Durolane dosing and administration guidelines ensures optimal results, providing patients with effective pain relief and improved joint function.

Prescribing Information

Durolane is suitable for patients with mild to moderate osteoarthritis who have not responded adequately to conservative treatments such as physical therapy, pain medications, or lifestyle changes. It is particularly beneficial for those seeking a non-surgical option to manage joint pain and improve mobility.

Prescribing information covers who should and shouldn’t get Durolane, safety tips, and possible side effects. It guides doctors in choosing the right patients for this treatment. This involves understanding who will benefit most from this therapy.

Durolane should not be used in patients with:

• Known hypersensitivity to hyaluronic acid or any of its components.
• Infections or skin diseases at the injection site.
• Severe inflammatory joint diseases other than osteoarthritis.

Precautions and Warnings

Before administering Durolane, it is crucial to screen patients thoroughly. Physicians should be cautious when treating patients with a history of bleeding disorders or on anticoagulant therapy due to the risk of bleeding at the injection site. The safety and efficacy of Durolane have not been established in pregnant or breastfeeding women, so it should be used with caution in these populations.

When comparing similar treatments like Durolane vs Synvisc, Durolane’s single-dose administration offers more convenience, but both treatments share similar precautions, especially regarding the risk of injection site complications.

Adverse Reactions and Side Effects

Common Durolane side effects include:

• Injection site reactions such as pain, swelling, redness, and warmth.
• Nausea, headache, and dizziness.
• Joint stiffness and muscle pain.

In rare cases, more severe reactions, such as allergic reactions, including hives, difficulty breathing, and swelling of the face or throat, may occur.

Conclusion

Durolane provides effective pain relief for knee and hip osteoarthritis for up to 26 weeks with just a single injection. Made from non-animal, clear hyaluronic acid gel, Durolane is injected directly into the joint to lubricate and cushion it. A local anesthetic is often administered beforehand to enhance comfort during the procedure.

Physicians adhere to strict dosage guidelines to ensure the safety and efficacy of the treatment, offering patients a convenient, long-lasting solution for joint pain relief.

FAQs

1. What is Durolane?

Durolane is a single-injection treatment containing hyaluronic acid, used to provide pain relief and improve joint function in patients with osteoarthritis.

2. Can Durolane be used for shoulder discomfort?

Durolane is FDA-approved for treating knee osteoarthritis, but its use for shoulder osteoarthritis is considered off-label. Always consult with a healthcare professional for personalized advice.

3. What side effects should I expect if I get Durolane injections?

Common side effects of Durolane injections include pain, swelling, and redness at the injection site, as well as headache and nausea. Serious side effects are rare but can include severe pain or swelling around the knee.

References

DUROLANE ® INSTRUCTIONS for USE. https://www.accessdata.fda.gov/cdrh_docs/pdf17/P170007D.pdf

SYNVISC® (Hylan G‐F 20) and Synvisc‐One® (Hylan G‐F 20) Dosing Information | For HCPs. www.synvisconehcp.com. https://www.synvisconehcp.com/dosing