David Fuller
Last Updated On: June 17, 2024
Botulinum toxin (BoNT) injections are one of the most popular solutions for dynamic wrinkles worldwide. In 2022 alone, over 7.3 million Botox injections were administered globally, making it the top nonsurgical cosmetic procedure in the world.
But beyond Botox, there are various BoNT-A injectables, including Nabota and Xeomin. These neurotoxins share the same active ingredient and treat similar aesthetic concerns. However, subtle differences exist. While both products yield comparable results, Nabota and Xeomin have been compared in terms of neurotoxin protein content and specific potency.
This article delves into the distinctions of Nabota and Xeomin, from their formulation to clinical efficacy, and compares these popular botulinum toxin injections.
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Nabota and Xeomin are popular botulinum toxin types used in beauty treatments to smooth wrinkles. Nabota is known for its effectiveness and FDA approval (under Jeuveau), making it a trusted choice. On the other hand, Xeomin is celebrated for its purified formulation, containing only botulinum toxin type A without added proteins, which may reduce the risk of allergic reactions.
Both are used to treat various medical conditions. Doctors consider the higher amount of inactive neurotoxin in Nabota versus Xeomin’s more straightforward formula when choosing between them. Real-world studies show minimal differences in safety and efficacy compared to other brands.
Nabota and Xeomin are distinctive because of their unique ingredients, which differentiate them from similar products.
Nabota and Xeomin are notable botulinum toxins with unique compositions. Xeomin is a purified botulinum toxin type A, free from complex proteins, containing only the essential neurotoxin. Meanwhile, Nabota includes additional proteins with its active ingredient, which can influence the body’s reaction to treatment.
This difference is crucial for medical professionals when choosing between Nabota, Xeomin, Botox, and Dysport for their patients.
Xeomin’s purity is a significant advantage, including proteins. Doctors appreciate this, as fewer proteins can mean fewer reactions. This makes Xeomin unique among treatments. Patients considering options like Nabota may find Xeomin’s straightforward, targeted action appealing.
Research indicates that both Nabota and Xeomin are effective in reducing the appearance of wrinkles and achieving a smoother skin texture. In a phase III trial comparing Nabota to Botox for essential blepharospasm, Nabota was found to be just as effective and safe as Botox. This supports using Nabota as a viable alternative to Botox for treating critical blepharospasm.
Xeomin has shown similar success to Botox and Nabota in various studies, highlighting its effectiveness. Xeomin has been proven to effectively and safely treat wrinkles on the upper face, including forehead lines, frown lines, and crow’s feet. It’s the first product in a phase III clinical trial to address all these areas at once.
Image courtesy of Phillips Aesthetic Dermatology
The patient experienced a successful treatment using Nabota (AKA Jeuveau) to rejuvenate the forehead area, resulting in longer-lasting effects on unwanted wrinkles.
Image courtesy of Avanti Medical Center
The patient achieved a smooth forehead using Xeomin neurotoxin injections. She received 36 units total: 20 units in her forehead and 16 units between her brows.
It’s important to note that Nabota and Xeomin share similar side effects, such as mild pain, swelling, or bruising at the injection site, as well as headaches or feelings of nausea. Professionals administering these treatments should closely follow instructions to avoid dosage errors.
Aspect | Nabota | Xeomin |
Key Composition | Contains complexing proteins and similar excipients as Botox | Purified botulinum toxin type A, free of accessory proteins |
Presence of Inactive Neurotoxin | Greater amounts compared to Xeomin | Free of therapeutically significant complexing proteins |
Clinical Efficacy | Efficacy in line with other botulinum toxin formulations | Studies show no significant differences in efficacy between Xeomin and Botox |
Side Effects | Similar to other botulinum toxins, it includes localized pain, swelling, and bruising | Comparable side effects reported cases of eyelid drooping, dry mouth, and headache |
Unique Consideration | It may require specific handling due to protein content | No refrigeration is needed due to the lack of accessory proteins, simplifying storage |
Understanding patient characteristics is crucial when selecting between Nabota and Xeomin for botulinum toxin treatments. Nabota is known for its high purity and consistent potency. This treatment is particularly suitable for patients seeking quick results, as it often shows effects within 2 to 3 days.
It is also beneficial for those concerned about developing resistance to botulinum toxins due to its low protein load, which minimizes the risk of antibody formation.
On the other hand, Xeomin is a “naked” botulinum toxin, meaning it contains no accessory proteins. This formulation can benefit patients who have previously developed resistance to other botulinum toxin products or those allergic to specific proteins. Xeomin’s onset of action is generally within 3-4 days, with effects lasting up to 3-4 months.
Due to their unique formulations, the dosing and administration techniques for Nabota and Xeomin differ slightly. In the Nabota mixing instructions, a typical dilution involves mixing 2.5 mL of saline for every 100 units, resulting in a concentration of 4 units per 0.1 mL. This dilution is then administered using fine needles to target specific muscle groups, ensuring precision and minimizing discomfort.
Xeomin requires a similar dilution process but is often praised for its ease of reconstitution due to the absence of complex proteins. The standard dilution for Xeomin depends on the vial size.
Nabota and Xeomin should be injected by trained professionals who can tailor the dosage and technique to the patient’s unique facial anatomy and aesthetic goals.
Doctors must manage their patients carefully to get the best results from treatments with Nabota or Xeomin. This involves understanding each patient’s needs and tailoring the treatment accordingly.
Nabota and Xeomin both offer unique benefits for smoothing wrinkles. Xeomin is focused on purity, while Nabota contains extra proteins. Both have shown promising results and safety in studies, providing choices for patients and their beauty goals.
Nabota contains additional proteins, while Xeomin is a pure-form botulinum toxin without added proteins.
Yes, but consult your doctor before making the switch.
Both typically last about 3-4 months before fading.
Both may have mild side effects, such as swelling or bruising at the injection site.
Xeomin may begin working slightly faster than Nabota in some cases.
Top nonsurgical cosmetic procedures globally 2019. Statista. https://www.statista.com/statistics/293449/leading-nonsurgical-cosmetic-procedures/
Kim D, Kim J. Safety and Efficacy of PrabotulinumtoxinA (Nabota®) Injection for Cervical and Shoulder Girdle Myofascial Pain Syndrome: A Pilot Study. Toxins. 2018;10(9):355. doi:https://doi.org/10.3390/toxins10090355
Reconstitution, dilution, and storage | XEOMIN®. https://www.xeomin.com/healthcare-professionals/reconstitution-and-storage
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