Orthovisc vs Euflexxa – A Thorough Comparison

Last Updated On: September 13, 2024

Viscosupplementation has shown promising results in managing knee osteoarthritis, with studies suggesting it can be more effective than NSAIDs (nonsteroidal anti-inflammatory drugs) and corticosteroids in reducing pain and enhancing joint function. Among the available options, Orthovisc and Euflexxa are popular choices for patients seeking long-term relief from knee pain.

Both Orthovisc and Euflexxa are FDA-approved hyaluronic acid injections that supplement the natural synovial fluid in the knee, providing lubrication and reducing friction within the joint. While they share similar purposes, each product has unique properties that may affect their effectiveness and suitability for different patients.

In this article, we will compare Orthovisc and Euflexxa, examining their composition, mechanism of action, clinical efficacy, and patient outcomes to help you make an informed choice.

Key Takeaways

• Viscosupplements like Orthovisc and Euflexxa, containing hyaluronic acid, offer promising results in managing knee osteoarthritis by replenishing diminished synovial fluid.
• Both Orthovisc and Euflexxa are FDA-approved hyaluronic acid injections designed to provide lubrication, reduce friction, and alleviate pain in the knee joints.
• Orthovisc is derived from rooster combs and requires four weekly injections and has shown effectiveness in alleviating pain and enhancing joint function in patients with knee osteoarthritis.
• Euflexxa is derived from bacterial fermentation and requires three injections over three weeks and has been found useful for relieving knee pain from osteoarthritis.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Orthovisc online, contact our sales department for more information.

Introduction to Viscosupplements for Osteoarthritis

Viscosupplements are injectable treatments that contain hyaluronic acid, a substance naturally found in the synovial fluid of joints. This fluid acts as a lubricant and shock absorber, facilitating smooth joint movement and reducing friction.

In the treatment of osteoarthritis, viscosupplements play a crucial role by replenishing the diminished hyaluronic acid in the affected joints. This helps to restore the natural lubrication and cushioning, thereby reducing pain and improving joint function.

Viscosupplements are particularly beneficial for patients who have not responded well to other treatments like NSAIDs or corticosteroids, offering a non-surgical option to manage symptoms and enhance quality of life.

Orthovisc

Orthovisc is a viscosupplement for knee osteoarthritis that mimics joint fluid. Following the proper Orthovisc dosage, the treatment provides lubrication and cushioning to alleviate pain and improve mobility. It is derived from rooster combs and requires four weekly injections for optimal results. 

It has also been widely studied for treating knee osteoarthritis (OA). Clinical trials, including randomized multicenter studies, show Orthovisc effectively alleviates pain and improves joint function in patients with mild to severe OA. It has a favorable safety profile compared to other hyaluronic acid preparations. 

Furthermore, literature reviews of 44 clinical trials underscore Orthovisc’s efficacy in reducing OA symptoms and enhancing quality of life. Ongoing research supports its potential as a promising treatment option for managing knee osteoarthritis, offering substantial relief and improved joint mobility.

Euflexxa

Euflexxa is another treatment for knee osteoarthritis that uses bacterial-derived hyaluronic acid. Euflexxa requires three injections over three weeks and has a slightly higher molecular weight than Orthovisc. 

Studies show that Euflexxa helps people with knee pain from osteoarthritis. On Drugs.com, it has a rating of 6.1 out of 10 based on 258 reviews, which shows that some patients find it useful for relieving pain.

Comparison of Orthovisc and Euflexxa

Orthovisc and Euflexxa both contain hyaluronic acid, but their sources differ. Orthovisc is derived from rooster combs, while Euflexxa uses bacterial fermentation to produce its hyaluronic acid. Both products aim to supplement the natural synovial fluid in the knee, providing lubrication and reducing friction to alleviate pain and improve joint function.

Orthovisc typically requires a series of three to four injections administered one week apart. On the other hand, Euflexxa is usually given in a series of three injections, which are also spaced one week apart. The treatment duration for both products is similar, with patients often experiencing relief for up to six months following the injections.

Cost Comparison and Insurance Coverage

The cost of Orthovisc and Euflexxa can vary depending on the healthcare provider and location. Both treatments are generally covered by insurance, but coverage specifics can differ. Patients are advised to check with their insurance providers to understand the extent of coverage and any out-of-pocket costs associated with these treatments.

Conclusion

Choosing between Orthovisc and Euflexxa depends on your needs. Orthovisc often relieves pain, while Euflexxa may be preferable for some patients. Consider factors like pain relief, injection frequency, and cost. Consult your doctor to determine which treatment aligns best with your specific needs and preferences.

FAQs

1. What distinguishes Orthovisc from Euflexxa?

Orthovisc is derived from rooster combs, while Euflexxa uses bacterial fermentation to produce its hyaluronic acid. This difference in source can influence patient preferences and potential allergic reactions.

2. How many Orthovisc injections are typically required?

Orthovisc typically requires a series of three to four injections administered one week apart.

3. Can Orthovisc be used for shoulder pain?

Doctors may typically prescribe Orthovisc for shoulder pain off the label, especially if a patient is suffering from shoulder osteoarthritis.

4. What are the potential side effects of Orthovisc?

Potential side effects of Orthovisc include pain, swelling, and redness at the injection site, as well as possible allergic reactions.

References

Peck J, Slovek A, Miro P, et al. A comprehensive review of viscosupplementation in osteoarthritis of the knee. Orthopedic Reviews. 2021;13(2). doi:10.52965/001c.25549

Knee Gel Injections (Viscosupplementation): Uses & Side Effects. Cleveland Clinic. Published 2024. https://my.clevelandclinic.org/health/procedures/knee-gel-injections-viscosupplementation

https://www.facebook.com/Drugscom. List of Viscosupplementation agents. Drugs.com. https://www.drugs.com/drug-class/viscosupplementation-agents.html