Rejuran vs Profhilo – Comparing The Two Products

Last Updated On: September 2, 2024

Injectable treatments like dermal fillers and skin boosters have gained immense popularity over the years for their ability to deliver quick, effective, and non-invasive skin rejuvenation. These procedures offer immediate results, making them a preferred choice for those seeking a youthful glow without surgery.

Rejuran and Profhilo are two standout treatments in this field. Rejuran is celebrated for its regenerative properties that promote skin healing, while Profhilo is renowned for boosting hydration and enhancing skin elasticity. Both cater to distinct skin concerns, providing tailored solutions for a more youthful appearance.

In this article, we’ll compare Rejuran and Profhilo, diving into their unique benefits, key differences, and guidance on choosing the best treatment for your needs.

Key Takeaways

• Rejuran and Profhilo are popular dermal fillers known for their skin rejuvenating properties.
• Rejuran uses salmon DNA (PDRN) to promote skin healing and reduce fine lines, while Profhilo contains hyaluronic acid to boost hydration and enhance skin elasticity.
• Rejuran is ideal for smoothing fine lines, while Profhilo is effective for treating dry, saggy skin.
• Both treatments offer long-lasting benefits, with Rejuran lasting 6 to 12 months and Profhilo lasting about 6 months, depending on skin type and lifestyle.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. Buy Rejuran at Med Supply Solutions today and stock your practice at wholesale prices!

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Introduction to Rejuran and Profhilo

Rejuran and Profhilo are popular dermal fillers that enhance skin appearance. Rejuran uses salmon DNA (PDRN) to repair skin, reduce fine lines, and improve texture. Profhilo contains hyaluronic acid, which hydrates and tightens the skin. Both treatments may cause slight swelling or redness but are effective. 

Rejuran is ideal for smoothing fine lines, while Profhilo excels at treating dry, saggy skin. Costs vary, as Rejuran may require more sessions than Profhilo. Each treatment offers long-lasting benefits, making them popular choices for achieving smoother, youthful skin. Many patients notice visible improvements after just one session.

Composition and Mechanisms of Action

Rejuran salmon DNA helps skin heal and look younger. Profhilo contains hyaluronic acid, which hydrates and tightens skin.

Rejuran: Salmon DNA (PDRN) Composition and How It Works

Rejuran salmon DNA (PDRN), which promotes skin healing and collagen production. This enhances firmness, smoothness, and repair. Rejuran reduces wrinkles and improves skin texture by signaling cells to repair, leading to noticeable results.

Profhilo: Hyaluronic Acid Composition and Its Mechanism of Action

Profhilo uses hyaluronic acid to hydrate and firm the skin. Unlike other fillers, it gradually releases hyaluronic acid to improve texture and firmness. The treatment stimulates collagen and elastin production, leading to smoother, youthful skin with natural-looking results.

Clinical Efficacy and Skin Concerns Addressed

Rejuran and Profhilo both show promise in rejuvenating skin, but they do so differently. Exploring their effects can help decide which filler best matches a patient’s needs.

On Rejuran

A Phase III clinical trial compared Rejuran® and Yvoire-Hydro® for treating crow’s feet. Rejuran® showed superior elasticity, collagen composition, and reduced wrinkle depth compared to Yvoire®, with similar durability and inflammatory response. The trial involved 72 patients over 12 weeks, with no unexpected adverse effects observed in either treatment.

Additionally, Rejuran®, a purified polynucleotide filler, has been studied for its efficacy and safety. In a Phase III clinical trial, Rejuran® demonstrated comparable efficacy to a hyaluronic acid filler for correcting crow’s feet, with no unexpected adverse effects. While more research is needed, these findings highlight the potential benefits of Rejuran® in addressing skin concerns.

On Profhilo

An observational pilot study evaluated Profhilo Structura®, which was injected into the lateral cheek fat compartment to restore adipose tissue. Participants experienced significant improvement in facial volume loss and wrinkle severity after the first treatment, with results maintained three months later. Wrinkles reduced, and skin firmness increased without serious adverse events. 

Clinical studies demonstrated Profhilo’s effectiveness in improving facial aging and skin texture and reducing laxity and fine wrinkles. The treatment showed a very low rate of complications and no adverse reactions. Additionally, comparative studies assessed Profhilo® alongside other treatments for facial and neck rejuvenation, providing valuable insights for practitioners.

Benefits, Side Effects, and Longevity of Results

Rejuran and Profhilo offer unique benefits for enhancing skin. Rejuran uses salmon DNA to boost collagen, improving elasticity and reducing wrinkles. Profhilo, with hyaluronic acid, hydrates and firms the skin, providing a natural look. Both treatments have mild side effects like swelling and redness, which usually subside quickly. 

Rejuran results can last 6 to 12 months, while Profhilo lasts about 6 months, depending on skin type and lifestyle. Both fillers deliver noticeable improvements, offering a temporary but natural enhancement to your skin’s appearance.

Practical Considerations and Patient Satisfaction

Treatment protocols for Rejuran and Profhilo differ because of their makeup and how they work on the skin. Knowing these steps helps medical professionals provide better care.

For Rejuran:

• Clean the skin well before starting.
• Mark the areas for injection carefully.
• Use a fine needle to inject Rejuran, made from salmon DNA, into the chosen spots.
• The amount used depends on the patient’s needs and the area being treated.
• After injecting, lightly massage the area to spread the product evenly.
• Patients may need more than one treatment to see full benefits.

For Profhilo:

• Start with a clean face.
• No need for marking, as Profhilo uses a technique targeting five key points on each side of the face.
• Inject Profhilo, which is hyaluronic acid-based, at these points using a specific method.
• The product spreads out naturally under the skin without massage.
• Typically involves two sessions spaced about a month apart.
• Results last for around six months before another treatment might be needed.

Patient Satisfaction and Real-life Experiences

People who use Rejuran, with its salmon DNA, often say their skin feels firmer and looks smoother. They notice fewer wrinkles and better texture after a few treatments. 

Image courtesy of Cheongdam

The patient achieved youthful, radiant skin with Rejuran Glass Skin Booster, which repairs the skin barrier and enhances hydration, texture, tone, and elasticity. It also effectively reduced fine lines and wrinkles.

Image courtesy of Brooklyn House of Beauty

The patient used Profhilo, a pioneering hyaluronic acid treatment with NAHYCO® technology. It effectively stimulates skin cell receptors to improve firmness, hydration, and elasticity, targeting areas like the face, neck, and hands.

Conclusion

Choosing between Rejuran and Profhilo depends on your needs. Rejuran is ideal for fine lines and texture, while Profhilo offers hydration and tightening. Both improve skin appearance; consult a doctor to find the best fit for your goals.

FAQs

1. What are Rejuran and Profhilo?

Rejuran and Profhilo are advanced skin boosters used for facial rejuvenation. Rejuran’s primary ingredient is salmon DNA.

2. How does Rejuran compare to Sculptra?

Rejuran and Sculptra both enhance the skin but differ in composition. Rejuran utilizes salmon DNA, whereas Sculptra contains a distinct active ingredient.

3. Can I choose between Rejuran and Profhilo?

Yes, the choice depends on your specific needs and desired treatment outcomes.

4. What are the key differences between these dermal fillers?

The main difference is their ingredients: Rejuran contains salmon DNA, which may impact their efficacy based on individual skin types.

References

McKeown DJ. Impact of Minimally Invasive Aesthetic Procedures on the Psychological and Social Dimensions of Health. Plastic and Reconstructive Surgery – Global Open. 2021;9(4):e3578. doi:https://doi.org/10.1097/gox.0000000000003578 

American Society of Plastic Surgeons. American Society of Plastic Surgeons. Published 2018. https://www.plasticsurgery.org/cosmetic-procedures/dermal-fillers/types 

The Art of Subtlety: Natural Results with Fillers – Premier Dermatology Group | Dermatology. Premier Dermatology Group | Dermatology – Premier Dermatology Group provides leading cosmetic and medical dermatology services. Published September 20, 2023. Accessed August 16, 2024. https://www.premierdermatologypartners.com/the-art-of-subtlety-natural-results-with-fillers/