Rejuran vs Sculptra – Which Is the Better Dermal Filler

Last Updated On: September 3, 2024

Injectable treatments have become a cornerstone in aesthetic medicine, offering non-surgical solutions for skin rejuvenation. According to the American Society of Plastic Surgeons, over 6.1 million filler procedures were performed in 2023, highlighting the increasing demand for minimally invasive options that restore volume and improve skin texture.

Both Rejuran and Sculptra stand out in enhancing skin rejuvenation through collagen stimulation. Both address different aspects of skin improvement: Rejuran focuses on cellular repair and surface texture, while Sculptra provides gradual, long-term volumization and tightening. They are sought-after for their ability to deliver natural-looking, effective results tailored to various skin concerns.

In this article, we’ll compare Rejuran and Sculptra, exploring their key differences, benefits, and ideal candidates to help you make an informed decision.

Key Takeaways

• Rejuran and Sculptra are both popular injectables that offer distinct benefits for treating signs of aging, with Rejuran focusing on cellular repair and surface texture, and Sculptra providing gradual, long-term volumization and tightening.
• Rejuran uses salmon DNA to repair fine lines and enhance skin health by promoting collagen production, while Sculptra uses poly-L-lactic acid to stimulate collagen growth, gradually filling deeper wrinkles and restoring lost volume.
• Rejuran is ideal for those seeking better skin texture and elasticity, while Sculptra is favored for addressing volume loss and deeper wrinkles.
• Both treatments have gained popularity in dermatology for their non-surgical approach to skin rejuvenation.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. Buy Rejuran online at Med Supply Solutions today and stock your practice at wholesale prices!

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Introduction to Rejuran and Sculptra

Rejuran and Sculptra are highly regarded dermal fillers that offer distinct benefits for treating signs of aging. 

• Rejuran uses salmon DNA to repair fine lines and enhance skin health by promoting collagen production. It’s particularly effective for fine lines and improving overall skin quality, with results lasting up to a year. 
• On the other hand, Sculptra uses poly-L-lactic acid to stimulate collagen growth, gradually filling deeper wrinkles and restoring lost volume, with effects lasting up to two years.

Both treatments have gained popularity in dermatology for their non-surgical approach to skin rejuvenation. While Rejuran is ideal for those seeking better skin texture and elasticity, Sculptra is favored for addressing volume loss and deeper wrinkles. 

Composition and Mechanism of Action

Rejuran is composed of polynucleotides (PDRN) derived from salmon DNA, which is biocompatible with human skin. The treatment works by promoting skin regeneration at a cellular level. When injected, Rejuran stimulates collagen production and accelerates tissue repair, improving skin elasticity and texture. The salmon DNA enhances the skin’s natural healing process, leading to smoother, more youthful skin with reduced fine lines and improved hydration.

Meanwhile, Sculptra is made from poly-L-lactic acid (PLLA), a biodegradable synthetic material. Unlike traditional fillers, Sculptra works gradually by stimulating collagen production deep within the skin. Once injected, PLLA particles trigger the body’s natural collagen-building process, helping to restore lost facial volume and smooth out deep wrinkles.

For those exploring options beyond Rejuran, some may compare Rejuran vs Profhilo as an alternative for skin hydration and rejuvenation, while Sculptra remains unmatched for deeper volume restoration needs.

Clinical Efficacy and Specific Skin Concerns

Rejuran and Sculptra tackle skin issues differently, showing unique strengths in clinical tests. Each filler excels at specific skin concerns, from wrinkles to volume loss, guiding choices for targeted results.

Image courtesy of Premier Clinic

Rejuran, or PDRN (Polydeoxyribonucleotide), uses salmon DNA fragments to stimulate collagen production and enhance tissue repair. This approach improves skin texture, reduces fine lines, and minimizes acne scars, offering natural-looking results. Unlike traditional fillers, which focus on volume, Rejuran rejuvenates skin without a “filled” appearance, making it ideal for targeted or overall skin improvement.

Image courtesy of The Luxxe Room

Sculptra, a poly-L-lactic acid-based dermal filler, stimulates natural collagen production to gradually restore volume and firmness. Unlike simple plumpers, it provides a subtle, long-lasting lift over several months. Ideal for sagging skin and hollow areas, Sculptra’s effects can last up to two years or more, offering a gradual and enduring transformation.

Benefits, Side Effects, and Longevity of Results

Exploring the benefits and side effects of Rejuran and Sculptra shows what each can do for the skin. Moreover, how long their results last gives us insight into their value over time.

On Rejuran

Rejuran offers multiple benefits, including improved skin texture, enhanced elasticity, and reduced fine lines. It’s particularly effective for those seeking overall skin rejuvenation and a healthier, more radiant complexion. The treatment also promotes faster wound healing and reduces inflammation, making it a popular choice for those looking to address early signs of aging.

• Common Side Effects: These may include mild redness, swelling, and slight bruising at the injection sites, but they’ll subside within a few days. Some patients may experience slight skin sensitivity, but this usually resolves quickly.
• Longevity of Results: The results can last 6 to 12 months, depending on individual factors like skin condition and lifestyle. A series of 3 to 4 treatments spaced 2 to 4 weeks apart is usually recommended for optimal results.

On Sculptra

Sculptra treatment offers significant benefits, including gradually restoring facial volume and reducing wrinkles. By stimulating collagen production, Sculptra helps to improve skin firmness and elasticity, resulting in a more youthful and natural-looking appearance. The treatment is particularly effective for addressing deep facial folds and hollow areas, providing long-lasting results.

• Common Side Effects: These may include redness, swelling, bruising, and tenderness at the injection sites. These side effects are generally mild and temporary, typically resolving within a few days to a week. Some patients may also experience small lumps under the skin, which usually diminish over time.
• Longevity of Results: The results can last up to 2 years or more, with most patients requiring 2 to 3 sessions spaced a few weeks apart to achieve optimal outcomes.

Practical Considerations

When deciding between Rejuran and Sculptra, understanding the treatment protocols, patient experiences, and cost is essential.

• Treatment Protocols: Rejuran treatments typically involve a series of micro-injections administered over multiple sessions, usually spaced a few weeks apart. The procedure is relatively quick and requires minimal downtime. Sculptra, on the other hand, requires a series of injections over several months, with sessions spaced about 4-6 weeks apart. Both treatments are performed in a clinical setting by a qualified professional.
• Patient Satisfaction and Experiences: Patients generally report high satisfaction with Rejuran and Sculptra treatments. Rejuran users often notice skin texture and hydration improvements, while Sculptra patients appreciate the gradual and natural-looking volumization. Both treatments are praised for their ability to enhance overall skin appearance without the need for surgery.
• Cost Considerations: The cost of Rejuran and Sculptra treatments can vary based on the provider, location, and the number of sessions required. Rejuran treatments may be slightly more affordable per session, but multiple sessions are needed for optimal results. Sculptra tends to be more expensive due to the longer-lasting effects and the need for fewer maintenance sessions. 

Conclusion

Deciding between Rejuran and Sculptra depends on your specific skin goals. Rejuran is ideal for enhancing skin texture, improving elasticity, and reducing fine lines, while Sculptra excels at restoring lost volume and addressing deeper wrinkles through collagen stimulation. To choose the best option, consider your skin’s unique needs, potential side effects, budget, and the desired longevity of results.

Both treatments offer distinct advantages tailored to different concerns, so understanding what each can achieve will help you make the most informed decision for your aesthetic goals.

FAQs

1. What is the difference between Rejuran and Sculptra?

Rejuran focuses on skin regeneration through cellular repair, while Sculptra targets volume loss by stimulating collagen production.

2. Which is better, Rejuran or Sculptra?

The choice depends on individual needs: Rejuran is ideal for skin rejuvenation and texture improvement, whereas Sculptra is suitable for restoring facial volume.

3. Are there any side effects of using these injectable treatments?

Both Rejuran and Sculptra can cause side effects such as redness or swelling at the injection sites.

4. Can I use both Rejuran and Sculptra together?

Yes, combining Rejuran and Sculptra can provide comprehensive results, but it is advisable to consult a professional before starting any new treatments.

References

Facial fillers for wrinkles – Mayo Clinic. www.mayoclinic.org. https://www.mayoclinic.org/tests-procedures/facial-fillers/about/pac-20394072 

Rejuran. Real science, real results. https://rejuranusa.com/pages/real-science-real-results

De Lima Menezes EDG, De Figueiredo Costa AC, De Sousa Neto JB, Maques JA, Santos MJ. EFFECTS OF SCULPTRA® (INJECTABLE POLY-L-LACTIC ACID) FOR FACIAL REJUVENATION: Health and Society. 2022;2(04):226-254. doi:10.51249/hs.v2i04.795