Synvisc Side Effects – Rare, Common, Long Term, Short Term

Last Updated On: August 8, 2024

Recent studies have shown that viscosupplementation, a treatment modality involving the injection of hyaluronic acid (HA) into joints affected by knee osteoarthritis, effectively reduces pain and improves functionality. However, understanding potential side effects is crucial.

Synvisc is a type of viscosupplement for knee pain in OA patients. Close monitoring during treatment is required to address adverse reactions and promptly ensure safety. This proactive approach enhances patient safety, improves treatment effectiveness, and ensures comprehensive care, increasing patient satisfaction.

This article explores the spectrum of Synvisc side effects, from mild to severe, and provides insights into managing and mitigating potential risks for informed decision-making.

Key Takeaways

• Swelling, pain, and stiffness at the injection site are typical but usually temporary. Monitoring can help manage these effectively.
• Although uncommon, Synvisc can cause infections or allergic reactions, highlighting the importance of immediate medical attention if severe symptoms arise.
• Most side effects appear shortly after injection and are generally mild, resolving within a few days to weeks.
• Long-term side effects are rare but can include persistent joint pain or mobility issues, necessitating ongoing evaluation and care.
• Regular monitoring ensures early detection and management of adverse reactions, optimizing treatment outcomes and enhancing patient safety and satisfaction.

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Common Short-Term Side Effects of Synvisc

After getting a Synvisc shot, some people feel pain or swelling where the needle went in. They might also see their skin turn red around that spot.

• Localized Pain at the Injection Site: This discomfort is temporary and typically lasts a few days as the body adjusts to the new substance. It is a normal response and usually subsides on its own. If pain persists or worsens, consult your healthcare provider.
• Swelling at the Injection Site: This side effect is common and results from the body reacting to the new substance. This swelling can make the area feel tight but usually resolves within a few days. Applying ice and resting can help alleviate it. Persistent swelling should be discussed with your doctor.
• Redness at the Injection Site: The injection site is red due to the body’s reaction to the injection. Typically, this redness fades within a few days. Ice packs or over-the-counter pain relievers may be used to manage discomfort. Monitor the area and consult a healthcare provider if redness worsens.

Rare but Serious Side Effects of Synvisc

Sometimes, Synvisc can cause big problems. It’s not common, but some people might face serious health issues after getting the shot.

• Infections at the Injection Site: Infections at the Synvisc injection site are rare but serious. Symptoms include increased redness, swelling, and heat. Early detection and treatment are crucial to prevent complications. Patients and medical professionals should monitor the site closely and report any unusual changes to ensure prompt intervention.
• Allergic Reactions: Though uncommon, allergic reactions to Synvisc ingredients can include itching, hives, or breathing difficulties. These serious reactions require immediate medical attention. Doctors should monitor for signs of allergies post-injection and educate patients on what symptoms to watch for to ensure timely treatment and safety.
• Severe Pain or Discomfort: Severe pain after Synvisc injections may indicate an adverse reaction. This is rare, but such pain should be investigated promptly. Medical professionals should assess for infections or allergic reactions and compare symptoms with those from similar treatments to ensure appropriate care and prevent further issues.

Long-Term Side Effects of Synvisc

After getting Synvisc, some Synvisc patients may have joint pain, stiffness, or trouble moving that lasts a long time. 

• Joint Stiffness: After Synvisc injections, joint stiffness can be reduced and create a sensation of tightness, especially in the morning or after periods of inactivity. To manage this, patients should work with their healthcare providers on exercises and treatment options, comparing Synvisc with alternatives like Monovisc or Orthovisc to find the best solution.
• Chronic Pain: This can persist beyond typical recovery periods, potentially causing joint stiffness and difficulty moving. Patients should report ongoing pain to their healthcare providers, who may recommend physical therapy or lifestyle changes to manage discomfort. 
• Decreased Range of Motion: A decreased range of motion can occur after Synvisc injections, making joints feel tight and less flexible. This may hinder daily activities and exercise. Regular check-ups and following advice on joint care can help manage this side effect, balancing rest with gentle movement to maintain mobility.

Managing Synvisc Side Effects

Handling side effects from Synvisc starts with good talks with your doctor. Always follow their advice on how to take care of yourself after getting the shot.

• Communicating with the Healthcare Provider: After a Synvisc injection, it’s crucial to inform your healthcare provider of any side effects you experience. This ensures prompt and appropriate care. Your doctor may adjust the dosage or recommend alternative treatments to manage symptoms. Follow their post-injection care instructions, including any advised activities or ice application.
• Following Post-Injection Care Instructions: Proper care of the injection site is essential. Keep the area clean and apply ice to reduce pain and swelling. Avoid putting pressure on the joint by steering clear of heavy lifting or intense exercise for a few days. If symptoms persist, such as redness or swelling, contact your doctor.
• Seeking Medical Attention: Knowing when to seek medical attention is vital. If you experience persistent pain, redness, swelling, signs of infection, or allergic reactions, consult a doctor immediately. Prompt treatment is essential for serious side effects. Monitoring your condition and reporting unusual symptoms ensures timely intervention and effective resolution.

Conclusion

Synvisc can effectively manage knee pain, but side effects such as swelling, redness, or, rarely, infections and allergic reactions may occur. Long-term use might lead to joint stiffness and decreased movement. Discuss potential risks and care tips with your doctor to manage side effects effectively.

FAQs

1. What are the common side effects of Synvisc? 

Common side effects of Synvisc include injection site pain, swelling, and fluid accumulation around the knee.

2. Can I experience rare side effects from using Synvisc?

Yes, although rare, severe allergic reactions are possible with Synvisc.

3. Are there long-term or short-term side effects with Synvisc use?

Short-term side effects include temporary discomfort, while long-term effects may involve persistent swelling or joint stiffness.

4. How should I respond if I notice any adverse effects after taking Synvisc?

Report any unusual changes, whether common or rare, to your healthcare provider immediately for appropriate evaluation and guidance.

References

Peck J, Slovek A, Miro P, et al. A Comprehensive Review of Viscosupplementation in Osteoarthritis of the Knee. Orthopedic Reviews. Published online July 10, 2021. doi:https://doi.org/10.52965/001c.25549 

Synvisc (Hylan G-F 20): Side Effects, Uses, Dosage, Interactions, Warnings. RxList. https://www.rxlist.com/synvisc-drug.htm