Synvisc vs Durolane – Which is the Better Treatment?

Last Updated On: August 8, 2024

In 2022, the viscosupplementation market was valued at USD 3.6 billion, driven by the high prevalence of osteoarthritis, especially among the aging population. This large figure is only expected to grow over the years, underlining the importance of these treatments for osteoarthritis.

Synvisc and Durolane are two popular viscosupplements used for this purpose. Synvisc is derived from rooster combs and acts as a lubricant and shock absorber, while Durolane is a non-animal-based hyaluronic acid product designed for long-lasting pain relief.

This article will compare Synvisc and Durolane to determine which treatment is better for managing knee osteoarthritis.

Key Takeaways

• Viscosupplements are injectable treatments used to alleviate pain and improve joint function in osteoarthritis patients.
• Synvisc and Durolane are two popular viscosupplements with different compositions, mechanisms of action, and treatment protocols.
• Synvisc typically requires multiple injections, while Durolane involves a single injection.
• Clinical studies and patient experiences can help individuals make an informed decision about which treatment may be more suitable for their needs.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Synvisc online, contact our sales department for more information.

Understanding Viscosupplements for Osteoarthritis

Viscosupplements are injectable treatments containing hyaluronic acid, a substance naturally found in joint fluid. These supplements help restore the cushioning and lubrication in arthritic joints, reducing pain and improving mobility. By injecting hyaluronic acid directly into the affected joint, viscosupplements enhance the quality of the synovial fluid, which deteriorates with osteoarthritis.

Choosing the right viscosupplement is crucial for effective treatment. Factors such as the severity of symptoms, patient response, and the product’s specific formulation influence the decision. Proper selection ensures optimal pain relief and improved joint function.

Synvisc

Synvisc is designed to alleviate knee pain from osteoarthritis and enhance joint movement. Made from hylan G-F 20, derived from chicken combs, Synvisc mimics natural joint fluid, acting as a lubricant and shock absorber. 

Synvisc is injected into the knee or shoulder to restore smooth movement and reduce discomfort. Doctors often recommend Synvisc when other treatments, such as painkillers or physical therapy, have not been effective. Its purpose is to provide immediate relief and long-term improvement in joint function.

Moreover, Synvisc has been extensively studied for treating knee osteoarthritis (OA). Clinical efficacy trials consistently demonstrate significant pain reduction for up to six months compared to baseline. This viscosupplement relieves chronic knee OA pain, making it a valuable option for patients.

Durolane

Durolane contains hyaluronic acid, which is naturally present in joints and aids smooth movement. Its unique NASHA (Non-Animal Stabilized Hyaluronic Acid) technology stabilizes the hyaluronic acid, effectively treating knee osteoarthritis with a single injection. This simplifies patient care and reduces clinic visits compared to other treatments requiring multiple doses.

Durolane’s high-purity hyaluronic acid acts as a lubricant and shock absorber, compensating for the natural joint fluid lost due to osteoarthritis. By injecting Durolane into the joint, its lubricating properties are enhanced, alleviating pain and improving function for up to six months.

Furthermore, Durolane has shown promise in numerous studies for managing osteoarthritis-related pain by adding lubrication and cushioning to affected joints.

A randomized, double-blind, 26-week non-inferiority trial compared Durolane (single injection) to Artz (five injections) for knee OA pain relief. Both treatments were effective, safe, and well-tolerated, with Durolane demonstrating non-inferiority over 18 and 26 weeks.

Durolane injections have a half-life of four weeks in the knee joint. A systematic review indicated that patients could expect pain relief from a single Durolane injection to last at least 182 days (6 months) and experience improvements in quality-of-life scores.

Comparing Treatment Protocols and Patient Experience

Doctors use Synvisc for osteoarthritis, requiring three injections into the knee, spaced one week apart. Each dose adds hyaluronic acid to enhance natural joint fluid, easing pain and improving movement. Many patients experience significant symptom relief for up to six months after completing the regimen.

Adhering to proper Synvisc dosage and guidelines helps manage osteoarthritis symptoms effectively. In contrast, Durolane simplifies treatment with a single injection, offering convenience and allowing patients to quickly return to their daily activities without multiple visits. Durolane’s streamlined process makes it a patient-friendly alternative to Synvisc.

Patient Satisfaction and Experiences

Synvisc patients often report reduced pain and improved mobility, though it requires multiple injections. Durolane, needing only one shot, provides a quick and convenient alternative. Both treatments may cause side effects like swelling or pain at the injection site, but most patients find the benefits, including significantly reduced pain and improved movement, outweigh these concerns.

Benefits and Side Effects

Synvisc and Durolane improve knee mobility for osteoarthritis patients. Synvisc typically requires several injections, while Durolane often needs just one. Both can enhance comfort but cause temporary pain, swelling, or stiffness. Although rare, serious side effects like infection or blood clots are possible. Despite this, many find relief and delay surgery with these treatments.

Synvisc vs Durolane – Making an Informed Decision

Deciding on Synvisc or Durolane for osteoarthritis treatment necessitates careful consideration. Both therapies aspire to alleviate discomfort and augment joint function, albeit via distinct methods. Here are some factors to ponder:

• Quantity of Injections: Synvisc usually requires three injections over several weeks, while Durolane needs only one.
• Relief Duration: Durolane often provides up to six months of relief from a single injection, compared to Synvisc, which may need more sessions.
• Patient’s Medical Background: Previous health conditions and potential allergic reactions can affect how patients respond to each treatment.
• Efficacy for Specific Joints: Effectiveness may vary depending on the affected joint and individual studies.
• Cost and Insurance Coverage: Insurance coverage can greatly impact the choice between Synvisc and Durolane.
• Patient Lifestyle and Preferences: Patients who prefer fewer doctor visits might lean towards Durolane’s single-injection approach.
• Potential Side Effects: Both treatments can cause swelling and soreness at the injection site; specific patient concerns should be considered.
• Result Speed: The speed of relief can differ, influencing choice for those seeking faster recovery.
• Research and Clinical Evidence: Stay updated on research as new findings may highlight the benefits of one treatment over the other for different osteoarthritis stages.
• Treatment Availability: The availability and expertise of local clinics with each treatment can influence the decision.
• Overarching Health Objectives: Align treatment options with the patient’s goals, such as pain relief, improved mobility, or avoiding surgery.

Conclusion

Choosing between Synvisc and Durolane depends on individual needs. Synvisc requires multiple shots, while Durolane needs just one. Consider your lifestyle and preferences for injections. Discuss with your doctor to determine the best option based on effectiveness, costs, and your comfort with treatment frequency.

FAQs

1. What are Synvisc and Durolane?

Synvisc and Durolane are viscosupplements used to alleviate knee pain caused by osteoarthritis. They supplement joint fluid to reduce discomfort and improve mobility.

2. How do these treatments compare?

Both Synvisc and Durolane provide pain relief for osteoarthritis but differ in composition and dosage frequency. Synvisc typically requires multiple injections, while Durolane usually needs only one.

3. Are there any side effects I should be aware of?

Both treatments may cause side effects such as swelling or redness at the injection site. Rarely, more severe reactions like fever or allergic responses can occur. Consult your doctor to discuss potential risks.

4. Which treatment is more effective, Synvisc or Durolane?

Effectiveness varies among individuals. Factors such as medical history, symptom severity, and lifestyle influence which treatment may be more beneficial. Consult your healthcare provider to determine the best option for you.

References

Viscosupplementation Market Size & Share | Trends Report, 2023 – 2032. Global Market Insights Inc. Accessed July 30, 2024. https://www.gminsights.com/industry-analysis/viscosupplementation-market

Al-Omran A, Azam Q. Efficacy of Viscosupplementation in Knee Osteoarthritis : A Clinical Trial of Three Agents. Bahrain Medical Bulletin. 2014;36(3):150-153. doi:https://doi.org/10.12816/0008107