Synvisc vs Euflexxa – Which is Better For Joints?

Last Updated On: August 8, 2024

Viscosupplementation, a treatment approach for knee osteoarthritis, has gained attention for its potential to alleviate pain and improve joint function. A recent systematic review and meta-analysis revealed that viscosupplementation offers modest pain relief and functional benefits. One study also demonstrated up to a 70% improvement in joint function compared to a placebo group

Synvisc and Euflexxa are both hyaluronic viscosupplements used to treat knee osteoarthritis. These injections, administered by healthcare specialists, enhance joint lubrication by supplementing the naturally occurring hyaluronic acid. Euflexxa is a bioengineered product that replaces hyaluronic acid in the knee joint, while Synvisc is derived from avian sources that offers similar benefits.

In this article, we will explore the efficacy, safety, and patient satisfaction associated with Synvisc and Euflexxa to help you decide which treatment may be better for joint health.

Key Takeaways

• Viscosupplements, such as Synvisc and Euflexxa, contain hyaluronic acid and are used to treat osteoarthritis by enhancing joint lubrication and cushioning, thereby reducing pain and improving mobility.
• Synvisc contains Hylan G-F 20 derived from chicken combs, while Euflexxa contains bioengineered hyaluronic acid sourced from bacterial fermentation.
• Synvisc requires only one injection for relief, which can last up to six months, while Euflexxa is highly purified through fermentation, offering its own set of unique advantages for joint problems.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Synvisc online, contact our sales department for more information.

Understanding Viscosupplements

Viscosupplements are injections containing hyaluronic acid, a substance naturally found in joint fluid. They are used to treat osteoarthritis by enhancing joint lubrication and cushioning, thereby reducing pain and improving mobility.

Synvisc works by injecting Hylan G-F 20, a gel-like substance derived from rooster combs, into the affected joint. This helps to mimic the natural synovial fluid, providing lubrication and shock absorption to alleviate pain and improve joint function.

Euflexxa, on the other hand, uses bioengineered hyaluronic acid sourced from bacterial fermentation. This non-animal hyaluronic acid supplement also works by replenishing the joint’s natural fluid, offering similar benefits in terms of pain relief and enhanced mobility.

Composition and Mechanism of Action

• Synvisc: Containing hylan G-F 20 derived from chicken combs, it mimics natural joint fluid to cushion and lubricate. Used to treat knee osteoarthritis, it is injected directly into the joint. By imitating the body’s own fluid, Synvisc smooths movement and reduces discomfort. Many patients find it effective for easing pain and improving mobility, making it a popular choice for managing osteoarthritis.
• Euflexxa: Euflexxa contains hyaluronic acid, a natural joint lubricant and shock absorber. It supplements the body’s declining hyaluronic acid levels due to osteoarthritis through injections into the knee. By mimicking healthy joint fluid, Euflexxa aims to restore joint balance, reduce pain, and improve mobility. Regular treatments can significantly enhance knee function and are often used alongside physical therapy for managing osteoarthritis.

Clinical Efficacy

Synvisc and Euflexxa show good results in easing osteoarthritis pain. Studies help us see which one might work better for different patients.

Efficacy and Safety of Synvisc

Synvisc (Hylan G-F 20) is an intra-articular treatment commonly used for knee osteoarthritis (OA). Clinical trials have demonstrated its efficacy and safety in managing chronic knee pain. Patients receiving Synvisc reported up to six months of pain relief. At the 12-month mark, individuals experienced a significant 44.8% reduction in pain compared to other viscosupplements. 

While Synvisc offers potential benefits, safety precautions are crucial. Synvisc is contraindicated in patients with known hypersensitivity to hyaluronan products or infections around the target knee. Adverse events may include transient pain, swelling, joint effusion, and other related symptoms. To minimize risks, a strict aseptic technique must be followed during injection.

Efficacy and Safety of Euflexxa

Euflexxa is a dual-acting treatment designed for osteoarthritis (OA) of the knee that has undergone rigorous clinical evaluation. In a 12-week trial, researchers compared Euflexxa to Synvisc in 321 patients with stage 2-3 OA. The primary endpoint was pain relief, measured by changes in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores. 

Remarkably, Euflexxa demonstrated robust pain relief, with patients experiencing significant improvement. A 26-week Flexx Trial involving 588 patients revealed Euflexxa’s superiority over saline in reducing OA knee pain. Patients remained pain-free even at the 6-month mark. These findings highlight Euflexxa’s potential as an effective therapeutic option for knee OA.

Benefits and Drawbacks

Exploring the pros and cons reveals Synvisc and Euflexxa both have unique advantages for joint problems. Both offer advantages for managing osteoarthritis symptoms, particularly in the knee.

• Synvisc: Synvisc contains hyaluronic acid, similar to natural joint fluid, which lubricates and cushions the joint, easing pain. It requires only one injection for relief, which can last up to six months. With a long track record of use, Synvisc is a reliable choice for osteoarthritis. Patients should learn about the Synvisc One pros and cons to make the right decision.
• Euflexxa: Euflexxa is highly purified through fermentation, reducing allergy risk for those sensitive to bird proteins. Its non-animal origin makes it suitable for patients with avian allergies. Clinical trials show significant pain relief for up to six months after a three-injection series, improving knee function and mobility.

Drawbacks of Synvisc and Euflexxa

Choosing between Synvisc and Euflexxa for joint treatment involves understanding their drawbacks. Both treatments have unique disadvantages that can affect patient experiences.

• Side Effects: Synvisc and Euflexxa can cause pain, swelling, or fluid buildup at the injection site. Due to their different compositions, allergic reactions may occur with Synvisc but are less likely with Euflexxa.
• Cost: Both treatments are costly, and insurance coverage varies widely, potentially making them unaffordable for many patients.
• Injection Frequency: Maintaining relief often requires multiple injections over time, leading to frequent doctor visits and additional costs.
• Effectiveness: Results can vary; some patients experience significant relief, while others may see minimal improvement in pain or mobility.
• Infection Risk: Infections at the injection site are a risk with any needle-based procedure, including Synvisc and Euflexxa.

Comparison of Pain Relief Duration, Side Effects, and Cost

Both Synvisc and Euflexxa have been shown to provide pain relief for osteoarthritis patients. Studies indicate that patients who haven’t found relief with other treatments (such as NSAIDs or physical therapy) have experienced pain relief lasting up to six months with hyaluronic acid injections. This extended duration can significantly improve the quality of life for those suffering from knee osteoarthritis.

Side Effects

Most side effects from both Euflexxa and Synvisc tend to lessen over time. However, if you experience any side effects that worsen or persist, it’s essential to consult your healthcare provider. In rare cases, seek emergency help immediately if you experience symptoms like shortness of breath or swelling of the face or throat.

Cost Comparison

When considering cost, Euflexxa is slightly more affordable than Synvisc. Although Synvisc One requires only one injection, the cost for a single dose is still higher than three Euflexxa injections. Therefore, patients and healthcare providers often weigh the overall cost against the longer duration of effects when choosing between these two treatments.

Patient Suitability and Expected Outcomes

Synvisc is suitable for patients with knee osteoarthritis who have not responded adequately to conservative treatments like pain relievers or physical therapy. Ideal candidates are typically those who can tolerate injections and do not have allergies to avian products. Patients can expect pain relief and improved joint mobility lasting up to six months.

At the same time, Euflexxa is designed for patients with knee osteoarthritis, particularly those seeking an alternative to avian-derived hyaluronic acid products. It is suitable for individuals who need long-term pain relief and improved joint function. Euflexxa users can expect pain relief and enhanced mobility for up to six months, with some experiencing benefits for a longer period.

Conclusion

Choosing between Synvisc and Euflexxa involves considering their benefits and drawbacks, including pain relief duration, side effects, and cost. Each treatment may suit different patients based on these factors. Consulting a healthcare provider is crucial for selecting the option that best fits individual needs and preferences.

FAQs

1. What are the advantages and disadvantages of Synvisc?

Synvisc offers long-lasting relief but may cause side effects or allergic reactions.

2. How does Synvisc compare to Durolane, Monovisc, Orthovisc, Hyalgan, and Euflexxa?

Each has unique benefits. The choice depends on individual needs and conditions.

3. Can Synvisc be used for shoulder pain?

Yes, some professionals may use Synvisc off-label to relieve shoulder pain, although it’s primarily used for knees.

4. What is the composition of Synvisc?

Synvisc contains Hylan G-F 20, a hyaluronic acid derivative that cushions and lubricates joints.

References

Pereira TV, Jüni P, Saadat P, et al. Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis. BMJ. Published online July 6, 2022:e069722. doi:10.1136/bmj-2022-069722

Joint Relief Institute. What is the Success Rate of Viscosupplementation? Joint Relief Institute. Published February 22, 2024. https://jointreliefinstitute.com/blog/what-is-the-success-rate-of-viscosupplementation/

Choosing the Right Hyaluronic Viscosupplement for Knee Osteoarthritis. Verywell Health. Accessed July 29, 2024. https://www.verywellhealth.com/euflexxa-vs-synvisc-5118452