Synvisc vs Hyalgan – Comparing Viscosupplements

Last Updated On: August 9, 2024

Viscosupplements are a widely used treatment for osteoarthritis, showing significant efficacy in reducing pain and improving joint function. According to a review published in Orthopedic Reviews, viscosupplementation can lead to substantial improvements in pain and function, particularly effective between 5 to 13 weeks post-injection.

Two widely used brands are Synvisc and Hyalgan. Both aim to alleviate osteoarthritis symptoms but differ in composition, treatment regimen, and effectiveness. Understanding these differences can help patients and healthcare providers make informed decisions about which treatment might best suit individual needs.

In this article, we will examine Synvisc and Hyalgan in detail, comparing their formulations, usage, benefits, and potential side effects.

Key Takeaways

• Synvisc and Hyalgan both treat osteoarthritis by lubricating and cushioning joints, but their effectiveness varies depending on individual patient responses.
• Synvisc requires three hyaluronan injections from chicken combs; Hyalgan involves five injections of purified sodium hyaluronate.
• Synvisc may provide relief for up to six months, while Hyalgan typically lasts three to six months.
• Both are well-tolerated, with possible side effects like pain and swelling at the injection site. Discuss allergies and conditions with a doctor.
• The choice between Synvisc and Hyalgan depends on individual needs and medical advice. Consult a healthcare professional for the best option.

About: Operating since 2016, Med Supply Solutions is known for being one of the industry’s top and trusted suppliers of cosmetic and viscosupplementation products. If you’re looking to buy Synvisc online, contact our sales department for more information.

Understanding Viscosupplements

Viscosupplements are injectable treatments that consist of hyaluronic acid (HA), a naturally occurring substance found in joint fluid. They are used to alleviate the symptoms of osteoarthritis (OA), particularly in the knees. Hyaluronic acid acts as a lubricant and shock absorber within the joint, helping to cushion and protect the bones during movement.

In osteoarthritis, the natural hyaluronic acid in the joint becomes diluted and less effective, leading to increased friction, pain, and inflammation. Viscosupplements work by replenishing the hyaluronic acid in the joint, restoring its lubricating properties. This helps to reduce pain, improve joint mobility, and potentially delay the need for more invasive treatments like surgery. 

Synvisc

• Active Ingredients: Synvisc is made of hylan A and hylan B polymers derived from hyaluronic acid, combined with a sodium chloride solution. Its high molecular weight helps mimic the natural synovial fluid in joints​​​.
• Treatment Protocol: Synvisc is administered through a series of three injections, one week apart. Alternatively, Synvisc-One offers a single larger dose for convenience, depending on the patient’s needs and the healthcare provider’s recommendation​​​.
• Mechanism of Action in Treating Osteoarthritis: Synvisc supplements the depleted hyaluronic acid in osteoarthritic joints, restoring lubrication and shock absorption. This reduces pain, improves joint mobility, and stimulates natural hyaluronic acid production, enhancing joint function over time​​​.

Hyalgan

• Active Ingredients: Hyalgan is composed of purified sodium hyaluronate, a form of hyaluronic acid. This biopolymer is derived from rooster combs and is designed to closely resemble the natural hyaluronic acid found in human synovial fluid​​​.
• Treatment Protocol: Hyalgan is typically administered as a series of five weekly injections directly into the knee joint. Each injection delivers a dose of hyaluronic acid to supplement the natural synovial fluid. In some cases, fewer injections may be effective, depending on the patient’s response and the severity of osteoarthritis​​​.
• Mechanism of Action in Treating Osteoarthritis: Hyalgan replenishes the natural hyaluronic acid in the synovial fluid, often depleted in osteoarthritic joints. This restores the fluid’s lubricating and shock-absorbing properties, reducing pain and improving joint mobility. By enhancing the viscoelasticity of the synovial fluid, Hyalgan helps protect the cartilage surfaces from further wear and tear, providing symptomatic relief and improving joint function over time.

Comparing Efficacy

Studies show how well Synvisc and Hyalgan work for arthritis knee pain. Doctors give their thoughts on which one is better.

On Synvisc

Clinical trials have shown that it provides superior pain relief compared to saline control and other treatments. Patients can experience up to six months of chronic knee OA pain relief. However, individual responses may vary, and it’s essential to consult a healthcare provider for personalized advice. While Synvisc is generally safe, precautions are necessary. 

On Hyalgan

Hyalgan (sodium hyaluronate) has been extensively studied in over 100 clinical trials worldwide. In a pivotal trial, two out of three patients receiving Hyalgan reported pain relief lasting up to six months. Repeat treatment cycles demonstrated sustained pain reduction for up to 30 months. Notably, patients with Kellgren-Lawrence grade 2-3 osteoarthritis (OA) showed significant clinical improvement when treated with Hyalgan. 

Side Effects and Safety Profile

Both Synvisc and Hyalgan are generally well-tolerated, but patients may experience some common side effects. These include:

• Injection Site Reactions: Mild pain, swelling, redness, and warmth at the injection site are common but usually resolve within a few days.
• Joint Pain and Stiffness: Some patients may experience temporary joint pain or stiffness following the injection

Safety Profile and Potential Risks

Synvisc and Hyalgan have similar safety profiles, with most adverse reactions being mild and self-limiting. However, there are some potential risks to consider:

• Local Inflammatory Reactions: Both treatments can cause local inflammation or swelling in the injected joint. These reactions are typically mild and resolve without intervention​​​.
• Infection: Although rare, there is a risk of infection at the injection site. Proper aseptic techniques can minimize this risk​​​.
• Allergic Reactions: Hypersensitivity reactions are uncommon but possible. Patients with known allergies to hyaluronic acid or avian proteins (for Hyalgan) should avoid these treatments​​​.
• Pseudoseptic Reactions: More commonly associated with Synvisc, these reactions involve severe inflammation mimicking an infection without actual bacterial presence​​​.

Cost Comparison

When considering viscosupplementation, cost plays a significant role. Here’s a brief overview of the cost differences between Synvisc and Hyalgan:

• Synvisc: Synvisc tends to be more expensive than Hyalgan. The average cost per injection ranges from $500 to $1,000. Some insurance plans may cover part of the cost, but patients often bear a substantial portion.
• Hyalgan: Hyalgan is generally more budget-friendly. The average cost per injection is around $300 to $600. Insurance coverage may vary, but Hyalgan is often more accessible for patients.

Patient Experiences and Testimonials

People who use Synvisc often share stories of how it helped them get back to their favorite activities. They talk about less knee pain and more movement after treatment. 

Synvisc Patients

• Anonymous: “Received one shot of Synvisc-one in both knees. The treatment worked well, no issues. My knees felt better. The treatment wore off about 6 months later, so went in for another treatment about 7 months after the first…“
• Honda Mike: “At 56 years old I run 8 mikes every day and 26 on Saturday. My knees hurt and I thought I would never run again. Three runners on my team had this injection and said it works. I had it 8 years ago. Immediate relief and still today I run pain free.”

Hyalgan Patients

• Roni: “I had osteoarthritis of the left knee about 6 years ago. Got 3 hyalgan injections and all pain was relieved. The shots lasted for 6 – 8 months, the pain returned, and I got another round of 3 shots. Each time, the pain went away completely.”
• Anonymous: “Hyalgan injections have worked for me immensely! My first round of 3 lasted a year. I just started my second round as I had a flare up. I hear some orthopedic surgeons feel there is no proof that it works and are convincing the insurance companies not to cover Hyalgan. They are saying it’s a placebo effect. I am living proof that it works for my osteoarthritis!”

Tips for Choosing the Right Viscosupplement

Choosing the right viscosupplement for osteoarthritis involves several factors. Compare treatments like Synvisc vs. Orthovisc or Hyalgan with your doctor. Synvisc mimics natural joint fluid to cushion and lubricate the knee, while Hyalgan uses hyaluronic acid to reduce friction and ease pain. Each treatment has different effects and costs, and insurance coverage may vary. 

Your doctor will assess your condition, discuss benefits and risks, and consider your activity level and lifestyle. This helps ensure you choose the most suitable option based on clinical evidence and personal health goals. Weight management and a healthy lifestyle are also crucial for maximizing treatment benefits.

Conclusion

Choosing between Synvisc and Hyalgan for osteoarthritis isn’t simple. Both have pros, cons, costs, and effects. Talking with a doctor helps you figure out the best choice for your health and lifestyle. Each person’s journey with these treatments is unique. Making an informed choice can lead to better comfort and mobility in daily life.

FAQs

1. What are Synvisc and Hyalgan? 

Synvisc and Hyalgan are viscosupplements used to treat osteoarthritis pain by injecting directly into the knee joint.

2. How do Synvisc and Hyalgan compare? 

Both aim to relieve osteoarthritis symptoms but differ in composition, dosage frequency, and side effects. Discuss these differences with a healthcare professional.

3. Can I switch between using Synvisc and Hyalgan? 

Switching is possible under medical supervision, considering your health history and response to treatments.

4. Are there side effects associated with Synvisc or Hyalgan?

Yes, potential side effects include swelling or discomfort at the injection site. Report any adverse reactions to your healthcare provider immediately.

References

Bellamy N, Campbell J, Welch V, Gee TL, Bourne R, Wells GA. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database of Systematic Reviews. Published online April 19, 2006. doi:https://doi.org/10.1002/14651858.cd005321.pub2