Synvisc vs Monovisc – Comparing OA Treatments

Last Updated On: August 8, 2024

Osteoarthritis (OA) is a major global health issue, affecting over 300 million people worldwide. Experts predict that by 2040, 78 million adults in the United States will suffer from this degenerative disease. Advanced technologies like viscosupplements offer promising solutions to alleviate joint pain and improve mobility for OA patients.

Two notable options are Synvisc and Monovisc. Both utilize hyaluronic acid injections to enhance joint lubrication and alleviate pain. Synvisc, derived from rooster combs, mimics synovial fluid, while Monovisc employs hyaluronic acid derived from bacterial fermentation. These treatments aim to restore viscoelasticity and improve joint function.

In this article, we’ll delve deeper into comparing Synvisc and Monovisc for knee OA management, examining their benefits, differences, and effectiveness.

Key Takeaways

• Synvisc and Monovisc help people with osteoarthritis by easing joint pain, such as knee pain. They work by mimicking the body’s own fluid to lubricate and cushion the joint.
• Both treatments involve injections, but Synvisc might require up to three shots, while Monovisc usually requires just one. This could make Monovisc more effective at seeing results.
• Side effects from both treatments can include pain, swelling, or warmth at the injection site. Yet, many patients report feeling better movement and less pain after getting these shots.
• The costs of Synvisc and Monovisc vary greatly, and insurance coverage plays a big role. Based on their health plan details, some patients may find one option more affordable.
• Doctors recommend considering factors like allergy history and how long relief lasts when choosing between Synvisc vs Monovisc for treating osteoarthritis symptoms.

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Understanding Osteoarthritis and Treatment Options

Osteoarthritis (OA) is a degenerative joint disease characterized by the breakdown of cartilage, the smooth tissue that cushions the ends of bones in joints. This degradation leads to pain, stiffness, swelling, and reduced mobility. OA primarily affects weight-bearing joints like the knees, hips, and spine, though it can occur in any joint.

Early intervention in OA is crucial to manage symptoms effectively and slow disease progression. Initial treatments often focus on lifestyle changes, such as weight management and physical therapy, to improve joint function and reduce pain. Early treatment can help preserve joint mobility, minimize pain, and delay the need for more invasive treatments like surgery.

Introduction to Synvisc and Monovisc

Synvisc is a viscosupplementation treatment that uses hylan G-F 20, a substance derived from rooster combs, to alleviate knee osteoarthritis (OA) symptoms. It mimics the properties of synovial fluid, providing lubrication and cushioning to the affected joint. Synvisc is typically administered in a series of three injections over several weeks.

Meanwhile, Monovisc is another viscosupplement used to treat knee OA. It employs a single injection of hyaluronic acid derived from bacterial fermentation. This high-molecular-weight hyaluronic acid acts similarly to natural synovial fluid, offering pain relief and improved joint mobility.

As for their administration, Synvisc requires three injections given one week apart, while Monovisc offers a more convenient single-injection regimen. A healthcare professional injects both into the knee joint, aiming to restore joint lubrication and reduce pain.

Synvisc vs Monovisc – Formulation and Mechanism of Action

Synvisc and Monovisc both use gel-like substances to relieve knee pain but differ in their formulations. 

• Synvisc: Derived from rooster combs, Synvisc mimics the natural joint fluid to cushion and lubricate the knee. This helps reduce pain and improve mobility. 
• Monovisc: Using a pure form of hyaluronic acid, Monovisc copies the natural joint fluid. Its single high-dose injection provides relief with fewer treatments compared to Synvisc, making Monovisc a more convenient option for managing osteoarthritis with less frequent injections.

Clinical Efficacy and Duration of Pain Relief

Studies and clinical trials have demonstrated the efficacy of Synvisc and Monovisc in alleviating pain and extending the duration of relief. These findings provide valuable insights into their effectiveness for osteoarthritis management. 

On Synvisc

Synvisc has consistently demonstrated superiority in clinical trials, providing long-lasting pain relief for knee OA. In head-to-head comparisons, it outperformed saline control and other treatments, making it a valuable option for patients seeking effective pain management.

Patients receiving three Synvisc injections can expect up to six months of relief from chronic knee OA pain. This duration makes Synvisc a compelling choice for those seeking sustained improvement in their joint discomfort. Always consult with a healthcare professional for personalized advice.

On Monovisc

In a pivotal phase III clinical trial involving 369 patients with knee OA across 31 centers in the US and Canada, Monovisc was rigorously evaluated. The study aimed to assess both safety and effectiveness, revealing that Monovisc provides durable pain relief with just a single high-dose injection. This convenience and efficacy make it an attractive option for patients seeking improved joint comfort.

Monovisc is a third-generation hyaluronan formulation designed specifically for single-injection regimens. Its 4 mL volume ensures ease of use for physicians and patient comfort. Early and lasting pain relief are key features, making Monovisc a valuable choice for managing knee OA symptoms.

Improvements in Joint Function

Both Synvisc and Monovisc are effective treatments for osteoarthritis, designed to enhance joint function. Synvisc typically involves three injections over several weeks, while Monovisc requires only one. This single-dose approach of Monovisc may offer quicker improvement for some patients. 

However, research shows that both treatments can substantially improve joint mobility and reduce pain for several months. Patients using either treatment often report better mobility and reduced pain, facilitating a return to preferred activities. Ultimately, choosing between Synvisc and Monovisc often depends on personal preference regarding the number of injections and the desired speed of relief.

When comparing more viscosupplementation treatments and discussing Synvisc vs. Durolane or Monovisc, a patient’s preference depends on the number of injections and the desired speed of relief.

Synvisc vs Monovisc – Side Effects and Patient Experiences

Both Synvisc and Monovisc can cause mild side effects, such as pain, swelling, and fluid buildup in the joint, with occasional warmth or redness at the injection site. These effects generally resolve on their own. Healthcare providers should monitor for rare signs of infection or allergic reactions. Understanding these side effects helps ensure informed patient care.

Patient Experiences and Testimonials

Patients report that Synvisc provides extended pain relief and easier walking, though some experience injection site swelling. Monovisc users also find relief and improved activity levels with fewer injections. 

Using Synvinc

• Suzan: “I’ve been having Synvisc injections every 6 to 7 months for the past 2 years…I’ll continue to get injections as they have made a significant improvement in the quality of life for me.”
• maple: “Excess fluid was aspirated from my knee prior to Synvisc-One injection…Swelling was minimal but pain lasted almost a week. 10 days into it, knee is feeling much better. I would do this again.”

Using Monovisc

• Burk: “I had a Monovisc injection almost 3 years ago after being told by my first doctor I needed knee replacement…Then he suggested I take the full dose of Monovisc, not smaller ones. He also explained that this only helps 50-60% of the people who take it. I am happy to say it has helped me.”
• Bel: “… I have been getting injections on both my knees for three years now. As long as I can continue getting Monovisc, my preferred remedy, I will, as knee surgery is out of the question for me. Love Monovisc!”

Doctors consider these patient testimonials, along with Synvisc’s multiple dosing options and alternatives like Orthovisc and Hyalgan, to tailor treatments effectively.

Cost Considerations and Insurance Coverage

Understanding the differences in cost and insurance coverage between Synvisc and Monovisc treatments can help medical professionals advise patients on osteoarthritis care options. Here’s a table to assist in those discussions.

Conclusion

Synvisc and Monovisc address osteoarthritis pain differently, with distinct ingredients and durations of relief. Both treatments offer significant pain reduction but have varying side effects and costs. Their choice depends on individual health needs, doctor’s advice, and budget considerations.

FAQs

1. What are the pros and cons of Synvisc One?

Synvisc One offers extended pain relief but may cause side effects such as swelling or discomfort at the injection site.

2. How does Synvisc compare to Hyalgan?

Both Synvisc and Hyalgan aim to relieve osteoarthritis symptoms, but their effectiveness can vary by individual. Some patients may find one more effective than the other.

3. Is Monovisc different from Synvisc?

Yes, Monovisc and Synvisc are different treatments for osteoarthritis. They have distinct formulations, and their choice often depends on individual patient needs and preferences.

4. Can I switch between these treatments if needed?

Switching between treatments like Synvisc, Monovisc, or Hyalgan is possible under medical supervision. Consult your healthcare provider before making any changes to your treatment plan.

References

SingleCare Team. Arthritis statistics. The Checkup. Published July 28, 2021. https://www.singlecare.com/blog/news/arthritis-statistics/ 

Dunn R. Comparison of Monovisc, Durolane, Synvisc, & Neovisc for Joint Osteoarthritis. The Knee Clinic. Published February 10, 2024. Accessed July 30, 2024. https://kneeclinic.ca/blog/2024/02/09/comparison-of-monovisc-durolane-synvisc-and-neovisc-in-the-management-of-joint-osteoarthritis/