Synvisc vs Orthovisc – Which is the Better Joint Treatment?

Last Updated On: August 8, 2024

Osteoarthritis (OA) is a degenerative joint disease that gradually wears down the protective cartilage within our joints. As the cartilage thins and becomes less resilient, the bones in the affected joint begin to rub against each other. This friction leads to pain, stiffness, and reduced mobility. The knee joint, being a weight-bearing joint, is particularly susceptible to OA.

Synvisc and Orthovisc are leading treatments for knee osteoarthritis. Synvisc, derived from chicken combs, mimics natural synovial fluid, while Orthovisc uses highly purified, non-animal-derived hyaluronic acid, catering to patients with sensitivities or preferences regarding animal-based products.

In this article, we will explore the differences and similarities between Synvisc and Orthovisc, examining their efficacy, safety profiles, patient satisfaction rates, and overall treatment protocols.

Key Takeaways

• Synvisc and Orthovisc are both viscosupplements used for treating osteoarthritis.
• Synvisc comprises hylan A and hylan B, while Orthovisc is made of highly purified hyaluronan.
• Both treatments provide lubrication and cushioning to the joints, reducing pain and improving mobility.
• Synvisc is administered in a series of three injections, while Orthovisc is given in a series of four or five injections.
• Side effects of both treatments are generally mild and temporary, with patient satisfaction varying based on individual responses.
• Factors to consider when choosing between Synvisc and Orthovisc include pain relief duration, treatment cost, and individual patient needs.

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Understanding Synvisc and Orthovisc

Synvisc and Orthovisc are treatments for joint pain, each with distinct ingredients and mechanisms. Synvisc contains Hylan G-F 20, miming natural joint fluid to lubricate and cushion joints, improving movement and reducing pain. Orthovisc, made from hyaluronan, also mimics natural joint fluid, offering similar lubrication and shock absorption. 

Both treatments are injected directly into the affected joint, where they reduce friction and wear, leading to less pain and better function. Understanding how Synvisc and Orthovisc interact with the body helps explain their effectiveness in relieving joint issues, whether for knees, shoulders, or other joints.

Treatment Protocols and Administration

When choosing how to treat joint problems, doctors examine how Synvisc and Orthovisc work. Each one has its steps for use and rules. The usual steps both treatments stick to are the following:

1. Pre-treatment Assessment: The healthcare professional reviews the patient’s medical history, conducts a physical knee examination, and performs imaging tests like X-rays to confirm osteoarthritis.
2. Injection Schedule: Synvisc requires three weekly injections, while Synvisc-One involves a single dose. Orthovisc requires three to four weekly injections.
3. Injection Procedure: The healthcare professional sterilizes the knee area, applies local anesthesia, and injects Synvisc or Orthovisc directly into the knee joint with a sterile syringe.
4. Post-injection Care: After the procedure, the administering professional advises patients to avoid strenuous activities for 48 hours and monitor for pain, swelling, or fluid build-up at the injection site.
5. Follow-up: Finally, the healthcare professional may schedule regular follow-up visits to monitor the knee and consider repeat injections every six months if needed.

Side Effects and Patient Satisfaction

Looking at side effects, both Synvisc and Orthovisc have their pros and cons. Patients often feel differently about how well each treatment works for them. While they are two different treatments, they have similar side effects:

• Pain, swelling, and warmth at the injection site
• Redness and tenderness around the joint
• Joint stiffness
• Fluid buildup in the knee (effusion)
• Rare allergic reactions
• Bruising

Patient Satisfaction for Each Treatment

Patient experiences play a crucial role in evaluating the effectiveness of any medical intervention. Understanding patient satisfaction provides valuable insights into viscosupplements like Synvisc and Orthovisc.

• Synvisc: Clinical studies report varying levels of satisfaction among patients. Some individuals find relief from pain and improved mobility after Synvisc injections. However, others may experience minimal benefits or transient effects. Factors influencing satisfaction include the severity of OA, individual response, and realistic expectations. Patients should be informed that multiple injections may be necessary for optimal results.
• Orthovisc: Some patients report significant pain reduction and enhanced joint function, while others may not experience substantial improvement.

Choosing Between Synvisc and Orthovisc

When faced with the decision between Synvisc and Orthovisc, several critical factors come into play. Here’s what patients and healthcare providers should consider:

Clinical Efficacy

• Synvisc: Clinical studies have shown varying results in terms of pain relief and joint function improvement. Some patients experience significant benefits, while others may not respond as favorably. Consider the severity of osteoarthritis and individual responsiveness.
• Orthovisc: Like Synvisc, Orthovisc’s efficacy varies. Some patients report substantial pain reduction and enhanced mobility, while others may find minimal relief. Assess the patient’s specific needs and expectations.

Safety Profile

Both products are generally safe, but individual reactions can differ. Allergic responses are rare but possible. Discuss any known allergies or sensitivities with patients.

Infection risk is minimal, but proper aseptic techniques during injection are crucial. Educate patients on post-injection care and signs of infection.

Treatment Schedule

• Synvisc: Typically administered as a series of three injections spaced over several weeks. Patients need to commit to the full course for optimal results.
• Orthovisc: Usually requires fewer injections (usually one to three), making it more convenient for some patients.

Cost Considerations

• Synvisc: The three-injection series can be costlier upfront. However, if it provides better and longer-lasting relief, it may be worth the investment.
• Orthovisc: Fewer injections may mean lower overall costs. Discuss financial implications with patients.

Patient Preferences

Some patients may prefer the natural source of Synvisc (derived from rooster combs), while others might favor Orthovisc (produced through bacterial cells). It’s important for healthcare professionals to discuss preferences, lifestyle, and treatment goals with patients.

Practical Advice for Making an Informed Decision

Choosing between Synvisc and Orthovisc for joint treatment requires careful consideration. Both options offer benefits, but the best choice depends on specific patient needs and clinical outcomes.

• To gauge their effectiveness, assess the patient’s medical history and previous treatments, such as Euflexxa, Durolane, Hyalgan, or even Synvisc vs. Monovisc.
• Compare Synvisc One pros and cons against Orthovisc, considering the onset of action, duration of relief, and patient tolerance.
• Consider the composition of Synvisc (hylan G-F 20) and potential allergies (e.g., bird allergies).
• Synvisc often requires fewer injections than Orthovisc, influencing patient convenience and compliance.
• Evaluate clinical benefits from studies, comparing outcomes like pain relief duration between Synvisc vs Euflexxa or Synvisc vs Durolane.
• Factor in side effects reported by patients using both treatments.
• Consider patient satisfaction scores to gauge overall treatment experience.
• Discuss with peers who have administered both treatments for diverse clinical insights.
• Review insurance coverage for each option; some plans might favor one treatment over another.
• Personalize the approach based on individual patient needs rather than relying solely on general comparisons like Synvisc vs Hyalgan.

Conclusion

Choosing between Synvisc and Orthovisc depends on patient needs, health conditions, and treatment responses. Both offer benefits, but doctors must weigh the pros and cons for each patient. An informed decision involves understanding both options, as there’s no one-size-fits-all answer. The right choice varies from person to person.

FAQs

1. What are Synvisc and Orthovisc?

Synvisc and Orthovisc are joint pain treatments made from hyaluronic acid. They differ in their specific formulations but share a common goal of alleviating joint discomfort.

2. How do Synvisc and Orthovisc compare?

The choice between Synvisc and Orthovisc depends on individual patient responses. Both treatments have distinct characteristics, and effectiveness varies from person to person.

3. Is Monovisc similar to Synvisc?

Monovisc is similar to Synvisc in that both are hyaluronic acid-based treatments. However, individual responses may determine which is more effective for a given patient.

4. Which treatment should I choose between Synvisc and Orthovisc?

The decision between Synvisc and Orthovisc should be based on personal health needs and responses. Consult with your doctor to determine the most suitable treatment option for your condition.

References

Media H. Viscosupplementation for Knee Osteoarthritis (Fact Sheet). Rheumatology Advisor. Published March 25, 2019. Accessed July 30, 2024. https://www.rheumatologyadvisor.com/home/topics/osteoarthritis/viscosupplementation-for-knee-osteoarthritis/ 

Orthovisc, Synvisc (hyaluronic-acid-and-derivatives) dosing, indications, interactions, adverse effects, and more. reference.medscape.com. https://reference.medscape.com/drug/orthovisc-synvisc-hyaluronic-acid-and-derivatives-999526