What is Liporase, And Where Can It Be Used?
HA-based dermal fillers have recently received special recognition in aesthetic medicine due to their almost complete safety for the human body. However, cross-threading of the polymer with BDDE (which is considered the least toxic agent) can have negative consequences for procedures with hyaluronic acid preparations.
Even after repeated cleaning, a certain quantity of free butanediol diglycidyl ether remains in the fillers, which can cause complications of various degrees – allergic reactions, inflammatory processes, infections with the formation of granulomas. In addition, there can be an excess of hyaluronic acid, the so-called “hypercorrection,” which shows up as unaesthetic results and the development of granulomas.
Usually, with the observance of safety measures and the doctor’s recommendations, side effects from injections with hyaluronic acid fillers develop exceptionally rarely. But according to the principle “forewarned is forearmed,” quickly eliminating unwanted reactions prevents serious health problems (necrosis, fibrosis, angioedema).
The fastest and most effective means to disarm these consequences and correct an excess of hyaluronic acid is hyaluronidase – a group of enzymes that cause hyaluronic acid in the body to be split into oligomers – low-molecular fragments. In this variant, the immune system ceases to perceive excess hyaluronic acid as foreign bodies, and the body naturally recovers.
When hyaluronidase is injected into an area where hyaluronic acid filler has been previously administered, it breaks down the hyaluronic acid molecules, allowing them to be absorbed and metabolized more rapidly by the body. This helps soften or dissolve the filler, resulting in a reduction in volume and correction of any undesired effects.
What Are The Indications for Liporase, And How Does It Work?
The South Korean drug Liporase contains the highly active depolymerizing enzyme hyaluronidase 1500 units, which breaks down excess hyaluronic acid into glucosamine and glucuronic acid. In addition, the drug increases the viscosity of hyaluronic acid, which contributes to changes within the dermis and connective tissue, improving the permeability of cell membranes.
The enzyme’s action favorably affects the vital activity of fibroblasts and the splitting of protein structures.
Liporase hyaluronidase is synthesized in the cytoplasm of cells and the intercellular space of the human body. This is a universal enzyme with a broad spectrum of action, thanks to which the bioavailability of many drugs administered subcutaneously or intramuscularly increases.
In cosmetology, Liporase is successfully used to rapidly eliminate hyaluronic acid to avoid undesirable consequences of injection procedures. However, Liporase is unsuitable for correcting excessive amounts of silicone, collagen, lactic acid, and calcium hydroxyapatite, as well as for hypersensitivity to them.
Initially, for aesthetic purposes, hyaluronidase was used to eliminate cellulite fibrosis, and later it started being widely used to treat undesirable consequences of hyaluronic fillers injections.
The unique properties of this enzyme contribute to the fragmentation of long links of hyaluronic acid and its natural removal from the body in the shortest possible time by the glands of internal secretion.
With a skillful selection of the Liporase dosage and a correctly chosen injection site, only 2-3 days are enough to eliminate the consequences of contour plastic surgery altogether.
Liporase may be needed in the following cases:
- Eliminating an excess amount of hyaluronic acid, which may not appear immediately after the procedure, but sometimes reveals itself only after several months or even years. It is essential to accurately determine the appropriate Liporase dosage for this task to prevent damage to molecules beyond the intended treatment area.
- Eliminating the signs of hypercorrection and migration of the HA drug, which often happens with the superficial injection of the gel, violation of the injection technique, or incorrect selection of the filler, for example, introducing dense gel into very thin areas of the skin. This can include overcorrection, uneven results, or the need for filler dissolution;
- Reducing the risks of edema and fibrosis after lipoplasty of the breast and chin area;
- Prevention of necrosis is one of the most insidious complications of contour plastic surgery, which develops due to a vascular embolism after mistakenly injecting stabilized hyaluronic acid into them. The problem is that some patients have a peculiarity – an abnormal arrangement of blood vessels. When the first symptoms of ischemia are detected, hyaluronidase should be administered immediately: after the first 24 hours following the procedure, its effectiveness will already be significantly lower;
- Correction of the Tyndall effect, which is manifested by the coloring of the skin in various unnatural shades;
- Enhancing the spread of dermal fillers: Liporase can facilitate the spread of hyaluronic acid fillers by breaking down the filler substance, allowing it to disperse more evenly within the treated area.
- Preparation for plastic surgery to remove scars;
- Preventing the formation of granulomas, which is a consequence of the inflammatory process at the injection sites, when the body begins to perceive fillers based on hyaluronic acid as a foreign element. The only effective treatment, in this case, is the introduction of Liporase hyaluronidase for the radical removal of the drug that provoked a negative immune response;
- Emergency treatment for vascular compromise: In rare cases, vascular compromise may occur following filler injections, impairing blood flow to the surrounding tissues. In such situations, Liporase can be used as an emergency treatment to help dissolve the filler and restore blood flow.
In all these cases, Liporase hyaluronidase is the fastest, most effective, and safest means of eliminating unwanted effects associated with injecting fillers based on hyaluronic acid.
When Liporase is injected into an area where hyaluronic acid fillers have been placed, the enzyme hyaluronidase degrades the hyaluronic acid molecules. Hyaluronidase breaks down the chemical bonds within the hyaluronic acid, breaking the filler material.
The enzyme cleaves the bonds between the sugar molecules in the hyaluronic acid structure. This process allows the hyaluronic acid to be rapidly metabolized and absorbed by the body and diminish or reverse the effects of hyaluronic acid fillers.
The speed at which Liporase breaks down the hyaluronic acid depends on various factors, including the concentration of the enzyme, the amount of filler present, and the specific characteristics of the hyaluronic acid used in the filler product.
The decision to use Liporase and the treatment plan should be determined individually, considering factors such as the patient’s medical history, specific concerns, and the doctor’s expertise.
A professional aesthetic doctor should always have an ampoule of hyaluronidase at hand: This is not an indicator of their fear of doing something wrong, but proof of the specialist’s high responsibility for the patient’s health and ideal aesthetic result.
Is Liporase Safe?
Liporrase is considered a safe option to remove HA products from the body, and according to Liporase reviews, it gets the job done.
But all medical procedures carry some degree of risk, and the safety of Liporase depends on several factors, including proper usage, dosage, individual patient characteristics, and the practitioner’s skill.
When used correctly, Liporase can help address complications or undesirable outcomes related to hyaluronic acid fillers by breaking down the hyaluronic acid molecules.
It is forbidden to use the enzyme in the case of:
- Inflammatory or infectious diseases;
- Increased allergic reaction;
- Oncological neoplasms;
- Hemorrhages risk.
During pregnancy and breastfeeding, injections with hyaluronidase are only possible in exceptional cases after a weighted assessment of the ratio of benefits for the mother and risks for the fetus or child. In addition, the time interval between injections with Liporase and other drugs is vital since hyaluronidase enhances the systemic effect of the latter and can lead to unexpected complications and side effects.
Rutin, organic silicon, extract of Melilotus, and Ginkgo biloba together with Liporase can’t be used.
Liporase is based on cellular cytoplasm and intercellular matrix using innovative technologies and multi-level purification. It does not contain harmful impurities and preservatives, is fully compatible with the body, and guarantees an immediate clinical effect after the first procedure.
Among the obvious advantages of using Liporase are the following:
- Fast and permanent result – all negative manifestations (redness, erythema, inflammation) disappear within a few days, and the skin returns to its natural state with the preservation of the optimal balance of native hyaluronic acid in the tissues;
- Economical consumption and simple preparation – the powder is diluted immediately before injection; only 1 ml of auxiliary agent (sodium chloride 0.9%) is required for one vial of the active substance. This makes the product economical when looking at the combination of Liporase price-quantity for single-use criteria;
- Multifunctional application – the drug can be injected both into the subcutaneous layer and into the deeper dermis; the choice depends on the degree of damage and severity of the aesthetic problem;
- Versatility, which allows the use of the enzyme not only in the correction of an excess of hyaluronic acid but also in the elimination of inflammation of various etiologies on the skin’s surface, the softening of postoperative scars, and the treatment of ulcerative neoplasms;
- Reversibility of the action – when the amount of hyaluronidase decreases, the density and viscosity of hyaluronic acid increase, which makes the action reversible.
To get the most optimal Liporase cost, buy hyaluronidase from Med Supply Solutions, an official Liporase supplier. We guarantee the product’s safety and authenticity for a competitive price.
Liporase Side Effects
Liporase is a protein substance with antigenic properties, sometimes leading to a local allergic reaction, such as swelling and redness at the injection site. Usually, such adverse reactions on the skin pass on their own within a few days.
Liporase has the following composition:
- Hyaluronidase (EP) 1500 IU;
- Lactose Hydrate 13.3 mg.
Liporase is manufactured as a powder of 1500 units, which is pre-mixed with a sterile physiological solution. It is important to remember that the drug is supplied in its pure form without preservatives and must be used immediately after dilution. The effect of the medicine lasts an average of 48 hours.