Key Features:

• Enzyme Function: Hyaluronidase specifically breaks down hyaluronic acid polymers, used for resolving filler excesses and granulomas.
• Rapid Results: Results are immediate, often visible within 1-2 hours of treatment.
• Formulation: Presented in a lyophilized form containing 1500 IU of hyaluronidase, to be mixed with sterile saline solution for injection.
• Target Areas: Primarily used to treat excess cross-linked hyaluronic acid and granulomas.
• Immediate Use: Must be used immediately after reconstitution with saline to ensure efficacy.
• Safety: Requires an allergy test prior to treatment, as hyaluronidase can trigger allergic reactions in sensitive individuals.

Indications:

• Excess Hyaluronic Acid: Hyaluronidase is most commonly used to dissolve excess hyaluronic acid caused by over-correction during dermal filler procedures, particularly in sensitive areas like the under-eye region.
• Granulomas: This enzyme helps to resolve granulomas, which are immune reactions to injected hyaluronic acid.
• Vascular Compression: Used to reduce the risk of skin necrosis caused by vascular compression due to excessive hyaluronic acid.

Contraindications:

• Active Skin Infections: Should not be used on areas with active infections or open wounds.
• Known Allergy: Not suitable for individuals with a known allergy to hyaluronidase or any of its components.
• Pregnancy and Breastfeeding: Not recommended during pregnancy or breastfeeding due to insufficient safety data.

Side Effects:

• Allergic Reactions: Hypersensitivity to hyaluronidase can occur, ranging from mild symptoms like itching or swelling to more severe reactions like anaphylactic shock.
• Skin Reactions: In some cases, redness, swelling, or temporary bruising at the injection site may occur.
• Delayed Reactions: Some patients may experience delayed itching or swelling after a few hours or days.

Ingredients:

• Hyaluronidase: The active ingredient, a natural enzyme, breaks down the long hyaluronic acid polymers into smaller components, making them easier for the body to absorb.
• Sterile Saline Solution: Used to reconstitute the lyophilized hyaluronidase before administration.

Packaging:

• Volume: Typically provided in 1.5 ml pre-filled syringes containing 1500 IU of hyaluronidase.
• Form: Lyophilized powder that must be mixed with sterile saline before injection.
• Syringe: Often paired with a 32G needle for precise injection into the treatment area.

• Method of Use:
  1. Reconstitution: Reconstitute the lyophilized hyaluronidase powder by mixing with sterile saline solution as per the product instructions.
  2. Allergy Testing: Perform an allergy test before the first use by injecting a small amount (0.1 ml) into the forearm. Monitor the area for any adverse reactions such as itching, redness, or swelling.
  3. Injection: Inject the reconstituted hyaluronidase directly into the areas where excess hyaluronic acid is present. For optimal results, use retro-injections or injections directly under the skin.
  4. Post-Treatment Care: Monitor for any immediate or delayed allergic reactions. Common side effects such as redness or swelling should subside within a few days.

  Frequency: Single injection sessions are often enough to resolve issues, but further treatments may be required in cases of severe over-correction or persistent granulomas.