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CRESPINE® GEL+ is a single, intra-articular injection of cross-linked and non-cross linked sodium hyaluronate, used to treat symptoms of osteoarthritis. The sodium hyaluronate is non-animal and ultra pure. CRESPINE® GEL+ is indicated as a viscoelastic supplement or a replacement for synovial fluid in human joints. CRESPINE® GEL+ offers the knee, hip, or other joint lubrication and mechanical support to relieve symptoms such as point pain. This product is for single-patient use only and must not be re-sterilized. Only qualified medical practitioners trained in injection techniques should administer CRESPINE® GEL+.

Quantity Discount (%) Price
1 $119.00
6 4.2 % $114.00
11 8.4 % $109.00
21+ 10.08 % $107.00
SKU: 88210 Tag:


CRESPINE® GEL+ is a viscosupplement injection containing both crosslinked and non-crossed linked sodium hyaluronate from a non-animal origin. This intra-articular implant is a highly pure, viscous gel that can help lubricate and cushion joints affected by osteoarthritis. The gel also contains Prilocaine, an anesthetic that helps make treatment more comfortable.

Why do doctors use CRESPINE® GEL+?

Doctors such as orthopedic surgeons, orthopedists, and rheumatologists use CRESPINE® GEL+ to help alleviate symptoms of osteoarthritis such as pain and poor joint function. The viscosupplement is suitable for the knee, the hip, or other joints affected by osteoarthritis, which is the breakdown of cartilage and synovial fluid within the joint. These patients may be affected by joint pain, limited movement, and other symptoms. Doctors may use CRESPINE® GEL+ to replace other treatments such as oral drugs, to supplement drugs or other treatments, or to delay knee or hip replacement surgery.

How CRESPINE® GEL+ works

CRESPINE® GEL+ is a viscous gel, similar to the synovial fluid found naturally in joints. The gel forms a layer on the surface of the cartilage, helping to lubricate the joint and cushion the joint with movement. This helps reduce the painful grinding of cartilage within the joint, helping reduce osteoarthritis pain and making movement easier for the patient. The Prilocaine within the gel is an anesthetic which can help relieve pain, making the injections more comfortable.

When and how to use CRESPINE® GEL+

The results of a CRESPINE® GEL+ treatment, involving a single injection, usually last about six to eight months, so you will likely repeat these treatments about every eight to ten months to maintain the results. Your patients will likely start to feel pain relief about five to seven days after the treatment. Only qualified medical professionals should administer CRESPINE® GEL+. To use CRESPINE® GEL+, first take a full medical history, advise your patient of precautions and possible adverse effects, and use an antiseptic to prepare the treatment area. Remove the syringe from its package, remove the cap covering the syringe tip, and attach a needle to the syringe. Before injecting the gel, minimize the chance of intravascular injection by performing aspiration first; if blood is present, reposition the needle. The absence of blood does not guarantee the injection is not into a blood vessel. Inject CRESPINE® GEL+ intra-articularly, into the synovial cavity of the affected joint. The injection technique is important to the outcome of a CRESPINE® GEL+ treatment. You can treat both knees or other joints, such as the hip, at the same time.

What is the difference between CRESPINE® GEL+ and CRESPINE® GEL?

CRESPINE® GEL+ and CRESPINE® GEL both contain sodium hyaluronate. However, CRESPINE® GEL+ also contains Prilocaine, an anesthetic that can help make injections more comfortable.

Can CRESPINE® GEL+ be combined with other osteoarthritis treatments?

You can combine CRESPINE® GEL+ injections with other osteoarthritis treatments, such as oral analgesics. The sodium hyaluronate injections can help reduce the dose of oral drugs your patients need to alleviate osteoarthritis symptoms.

CRESPINE® GEL+ side effects

Side effects of CRESPINE® GEL+ can include:


  • Pain
  • Temporary redness
  • Swelling
  • Sensation of heat
  • Reduced mobility


Rarer CRESPINE® GEL+ side effects can include:


  • Signs and symptoms of depressed cardiovascular function from a vasovagal reaction
  • Hypersensitivity reaction with erythema (redness) and swelling
  • Allergic reaction with skin lesions, urticaria (hives), edema (swelling), or anaphylaxis


Possible side effects of high doses of Prilocaine:


  • Persistent paraesthesia (tingling, numbness, or burning sensation)
  • Light-headedness
  • Nervousness
  • Apprehension
  • Euphoria
  • Confusion
  • Dizziness
  • Drowsiness
  • Tinnitus
  • Blurred or double vision
  • Vomiting
  • Sensations of heat, cold, or numbness
  • Twitching tremors
  • Convulsions
  • Unconsciousness


Most side effects usually spontaneously disappear within two to five days. Hypersensitivity reactions are usually mild to moderate and last less than two weeks. These may not be all the possible side effects of CRESPINE® GEL+.

Precautions when using CRESPINE® GEL+

Do not use CRESPINE® GEL+ if your patient is allergic or hypersensitive to hyaluronic acid, Prilocaine, or other anesthetics. There is no clinical data on the use of CRESPINE® GEL+ during pregnancy and there is no clinical data on the use of CRESPINE® GEL+ during breastfeeding, so use caution in these cases. Use caution when treating patients under the age of eighteen with CRESPINE® GEL+ because no clinical data is available. Avoid injecting the viscosupplement into an area affected by infection or inflammation. Use caution when treating patients with symptoms of cardiac conduction disorders. Use caution when treating patients with cardiac impairment or impaired renal or liver function because these patients may reach toxic concentrations of Prilocaine earlier. Before treatment, your patients should avoid taking anticoagulants such as aspirin, steroids, or high doses of vitamin E because these drugs and supplements can increase the risk of bleeding and inflammation. Do not mix CRESPINE® GEL+ with other injection agents. Always have proper training and supplies ready for emergencies, such as oxygen, resuscitative equipment, and resuscitative drugs. This viscosupplement injection is for single use only; do not resterilize the gel or reuse the same gel-filled syringe on another patient. Do not use CRESPINE® GEL+ if the package is open or defective. After injection, properly dispose of the syringe and needles.

CRESPINE® GEL+ contraindications

Do not use CRESPINE® GEL+ in the event of:


  • Autoimmune disease
  • An incompatibility with gram-positive bacteria
  • Active inflammation or infection
  • Anticoagulant therapy
  • Known allergy to hyaluronic acid
  • Known hypersensitivity to amide local anesthetics
  • Congenital or idiopathic methemoglobinaemia or severe anaemia in children


CRESPINE® GEL+ interactions

When combined with other drugs known to cause formation of methemoglobinaemia, such as sulfonamides, acetaminophen, acetanilide, aniline dyes, benzocaine, chloroquine, dapsone, napthalene, nitrates and nitrites, nitrofurantoin, nitroglycerin, nitroprusside, pamaquine, para-aminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, and quinine, the Prilocaine in CRESPINE® GEL+ can contribute to this condition. This is also true of patients with a glucose-6-dehydrogenase deficiency. Using CRESPINE® GEL+ with beta blockers may prolong the anesthetic effect.

Does CRESPINE® GEL+ require a skin test?

CRESPINE® GEL+ is made of sodium hyaluronate from non-animal sources, so it is safe for patients with egg or other avian allergies. The gel is also highly pure and free of endotoxins. A hypersensitivity reaction to CRESPINE® GEL+ is possible.

How to store CRESPINE® GEL+

Store CRESPINE® GEL+ at room temperature, between 2° C and 25° C. Do not freeze the gel or expose it to extreme heat. Keep out of the reach of children.

Where to buy CRESPINE® GEL+

You can order CRESPINE® GEL+ online from or you can phone our friendly customer service associates to order this and other medical supplies. When you order CRESPINE® GEL+ from Med Supply Solutions, you can help your patients relieve their osteoarthritis symptoms for more comfortable movement.

Information about this product that is provided by is only summary, and does not cover all of the information about this product.


* Med Supply Solutions offers only genuine CRESPINE® GEL+ that is manufactured by BioPolymer GmbH. All brands listed here including CRESPINE® GEL+ are the trademarks of their respective owners. Med Supply Solutions is not operated by, supported by or affiliated with BioPolymer GmbH.



Active Substance(s)

Sodium hyaluronate, lidocaine


14mg/ml, 3mg/ml

Pack Size

1-2ml prefilled syringe


Package insert, 4 traceability labels

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