DUROLANE®

DUROLANE is a single-injection treatment of HA designed to provide powerful and lasting pain relief due to Osteoarthritis pain in the ankle, shoulder, elbow, wrist, fingers, and toes. DUROLANE is a HA which acts like a lubricant and shock absorber in the synovial fluid. A DUROLANE injection may cushion the joint and manage the symptoms. DUROLANE is also indicated for pain following joint arthroscopy in the presence of osteoarthritis within three months of the procedure.

Symptomatic treatment associated with mild to moderate osteoarthritis pain in the hip, knee, ankle, shoulder, elbow, wrist, fingers, and toes. DUROLANE is also indicated for pain following joint arthroscopy in the presence of osteoarthritis within three months of the procedure.

DUROLANE is intended to be used for intra-articular injection for the symptomatic treatment of mild to moderate knee or hip osteoarthritis. It should be injected by an authorized physician, or in accordance with local legislation. Additionally, DUROLANE is intended to be used for intra-articular injection for symptomatic treatment of mild to moderate osteoarthritis of indicated synovial joints, and for pain following arthroscopic procedures in the presence of mild to moderate osteoarthritis. It should be injected by an authorized physician, or in accordance with local legislation. DUROLANE contains 20 mg/mL of stabilized nonanimal hyaluronic acid in buffered physiological sodium chloride solution pH 7. DUROLANE is a sterile, transparent viscoelastic gel supplied in a 3 mL glass syringe. The product is for single use only. Hyaluronic acid belongs to a group of very few substances which are identical in all living organisms. It is a natural polysaccharide that is present throughout the tissues of the body, with particularly high concentrations in the synovial fluid and the skin. DUROLANE is composed of biosynthetically produced hyaluronic acid which has been purified and stabilized. DUROLANE is degraded in the body by the same metabolic pathway as endogenous hyaluronic acid.

Patient Preparation:

The patient should be in a comfortable position that allows easy access to the joint. The skin over the joint is cleaned with an antiseptic to minimize infection risk.

Anesthesia:

Local anesthesia may be used to numb the area where the injection will be given. This could be a topical anesthetic or a local anesthetic injection.

Aspiration:

If there is any excess fluid in the joint, your healthcare provider may need to remove it before injecting Durolane.

Injection:

The Durolane syringe is prepared according to the manufacturer's instructions. The healthcare provider will then inject Durolane directly into the joint space. Ultrasound guidance may be used to ensure accurate placement of the injection.

Contraindications

DUROLANE should not be injected if the patient is known to be sensitive to hyaluronic acid-based products.

After-care:

Following the arthroscopic procedure, intra-articular injection should be performed outside the sterile field as the exterior of the syringe is not sterile. Joints that typically undergo arthroscopic procedures are the knee, hip, shoulder, elbow, ankle, and wrist joints. Avoid strenuous activity (e.g. tennis, jogging, or long walks) the first two days after the injection. Some transient reactions related to the injection of DUROLANE, such as pain and/or swelling/stiffness of mild to moderate intensity during the first week following the injection can be anticipated. If the symptoms last for more than a week a physician should be contacted.