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Etermis 4 can be purchased to offer treatment options for patients suffering from more severe wrinkles and lines. The product contains a higher level of hyaluronic acids than the other products in its line. This makes it more effective in reducing signs of aging in advanced stages. This can cause deep lines and wrinkles as well as noticeable skin sag.

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What makes a good candidate?

The product can be applied to any patient over 18 years old. It is not a good idea to start a skincare regimen against the signs of aging too soon. Etermis 4 should only be used on patients who have already begun to notice the signs of aging. This treatment can be used to treat severe wrinkles, even if you haven’t noticed any.

Areas treated with Etermis4

Etermis 4 can be used to smoothen out lines and wrinkles around the eyes. Etermis 4 can also be used to give the affected area a rejuvenating effect that makes the skin look healthier and more natural. This treatment can also be used to fill in the lips, which is a common sign that you are getting older.

What does Etermis 4 do?

Etermis 4 is an ophthalmic gel that is completely free from pyrogens. It is made up of non-animal-sourced cross-linked Hyaluronic Acid at a concentration 24 mg/ml. This gel was designed to treat wrinkles and deep lines. It can treat larger areas of the skin, such as the forehead and cheeks. Also, it can be used on areas that are more sagging, like the chin or near the nose. Skin becomes duller due to decreased collagen production and synthesis, diminished fibroblasts, and perturbations that come with aging. This can also lead to skin losing volume and leading to skin sagging. Etermis 4 is a mixture that was designed to counter this problem. It can also be used to fill in the lips with volume loss. It contains the plant-origin, sodium phosphate buffer and mannitol. This antioxidant acts as a scavenger for free-radicals. It will reduce hyaluronic acids degradation and make them last longer.

Treatment Details

Only professional medical professionals should apply this product. They must have the necessary training and experience to perform these types of procedures. Before the product is injected, it should be cleaned in the targeted area. The patient must also be informed about the expected outcome. The injection is done through the deep dermis with a Hyaluron Pen or cannula. To ensure the distribution of the solution throughout, you should gently massage the area after injection.

How long does Etermis 4 last?

It is dependent on the lifestyle and physiology, so the exact time the product will last will vary from one case to the next. The solution generally shows results up to 12 months after injection. The doctor may recommend additional treatment or maintenance depending on the results. This is necessary if the patient wants to see more results.

Safety Information

Etermis 4 has been CE-marked and has proven to meet regulatory safety standards. However, there are some contraindications that still exist and may prevent some patients from using this product. These include being pregnant, nursing, or under the age of 18. Etermis 4 injections should be avoided if the patient is known to have hypersensitivity to any component. Infections or inflammation should also be avoided. This solution should not be used in areas that have been treated with permanent fillers.

Other Side Effects

As a countermeasure to wrinkles, swelling, redness and inflammation are common side effects of this product. You may experience slight pain, bumps and sensitivity in the area where this product is used. These effects should resolve themselves in a few days. If they don’t, it is advisable to consult your doctor immediately.

Recovery Time

There is very little downtime after treatment, if at all, especially if there are no side effects. Patients can resume their normal daily activities after treatment. However, patients should avoid overexposure to sun and strenuous activities for the first 24 hour to ensure that the solution is properly absorbed and signs of improvement.


Merz Pharmaceuticals

Active Substance(s)

Hyaluronic acid, mannitol



Pack Size

2-1ml prefilled syringes


Package insert, 2-27G 1/2" needles, 2-25G 1" needles, 4 traceability labels

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